Title:
IMMUNOGENIC COMPOSITION OR VACCINE AGAINST GRAM - NEGATIVE BACTERIAL, FOR EXAMPLE NEISERIAL, INFECTION OR DISEASE
Document Type and Number:
WIPO Patent Application WO/2011/110655
Kind Code:
A3
Abstract:
The present invention relates to the field of Gram-negative bacterial immunogenic compositions and vaccines, their manufacture and the use of such compositions in medicine. More particularly, it relates to immunogenic compositions comprising outer membrane proteins of Gram-negative bacteria which are involved in uptake of extracellular zinc.
Inventors:
DEVOS NATHALIE ISABELLE (BE)
POOLMAN JAN (BE)
STORK MICHIEL (NL)
TOMMASSEN JOHANNES PETRUS MARIA (NL)
WEYNANTS VINCENT (BE)
POOLMAN JAN (BE)
STORK MICHIEL (NL)
TOMMASSEN JOHANNES PETRUS MARIA (NL)
WEYNANTS VINCENT (BE)
Application Number:
PCT/EP2011/053665
Publication Date:
November 03, 2011
Filing Date:
March 11, 2011
Export Citation:
Assignee:
GLAXOSMITHKLINE BIOLOG SA (BE)
UNIV UTRECHT (NL)
DEVOS NATHALIE ISABELLE (BE)
POOLMAN JAN (BE)
STORK MICHIEL (NL)
TOMMASSEN JOHANNES PETRUS MARIA (NL)
WEYNANTS VINCENT (BE)
UNIV UTRECHT (NL)
DEVOS NATHALIE ISABELLE (BE)
POOLMAN JAN (BE)
STORK MICHIEL (NL)
TOMMASSEN JOHANNES PETRUS MARIA (NL)
WEYNANTS VINCENT (BE)
International Classes:
C07K14/22; A61K39/095; A61P31/00
Domestic Patent References:
| WO2000071725A2 | 2000-11-30 | |||
| WO2001085772A2 | 2001-11-15 | |||
| WO2007148363A1 | 2007-12-27 | |||
| WO2000055327A2 | 2000-09-21 | |||
| WO1999057280A2 | 1999-11-11 | |||
| WO2000011182A1 | 2000-03-02 | |||
| WO2010025964A1 | 2010-03-11 |
Other References:
CHEN ET AL: "Identification and characterization of a high-affinity zinc uptake system in Neisseria gonorrhoeae.", FEMS MICROBIOLOGY LETTERS, vol. 202, no. 1, 1 August 2001 (2001-08-01), pages 67 - 71, XP055001190, ISSN: 0378-1097
PATZER SILKE I ET AL: "The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli", MOLECULAR MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 28, no. 6, 1 June 1998 (1998-06-01), pages 1199 - 1210, XP002453143, ISSN: 0950-382X, DOI: DOI:10.1046/J.1365-2958.1998.00883.X
CAMPOY SUSANA ET AL: "Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar typhimurium virulence", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 70, no. 8, 1 August 2002 (2002-08-01), pages 4721 - 4725, XP002453141, ISSN: 0019-9567, DOI: DOI:10.1128/IAI.70.8.4721-4725.2002
TURNER PAUL C ET AL: "Neisserial TonB-dependent outer-membrane proteins: Detection, regulation and distribution of three putative candidates identified from the genome sequences", MICROBIOLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 147, no. 5, 1 May 2001 (2001-05-01), pages 1277 - 1290, XP009121702, ISSN: 1350-0872
VIPOND C ET AL: "Characterization of the protein content of a meningococcal outer membrane vesicle vaccine by polyacrylamide gel electrophoresis and mass spectrometry", HUMAN VACCINES, LANDES BIOSCIENCE, GEORGETOWN, TX, US, vol. 1, no. 2, 1 January 2005 (2005-01-01), pages 80 - 84, XP008085859, ISSN: 1554-8600
STORK MICHIEL ET AL: "An Outer Membrane Receptor of Neisseria meningitidis Involved in Zinc Acquisition with Vaccine Potential", PLOS PATHOGENS, PUBLIC LIBRARY OF SCIENCE, SAN FRANCISCO, CA, US, vol. 6, no. 7, 1 July 2010 (2010-07-01), pages E1000969 - 1, XP009148766, ISSN: 1553-7366
PATZER SILKE I ET AL: "The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli", MOLECULAR MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 28, no. 6, 1 June 1998 (1998-06-01), pages 1199 - 1210, XP002453143, ISSN: 0950-382X, DOI: DOI:10.1046/J.1365-2958.1998.00883.X
CAMPOY SUSANA ET AL: "Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar typhimurium virulence", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 70, no. 8, 1 August 2002 (2002-08-01), pages 4721 - 4725, XP002453141, ISSN: 0019-9567, DOI: DOI:10.1128/IAI.70.8.4721-4725.2002
TURNER PAUL C ET AL: "Neisserial TonB-dependent outer-membrane proteins: Detection, regulation and distribution of three putative candidates identified from the genome sequences", MICROBIOLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 147, no. 5, 1 May 2001 (2001-05-01), pages 1277 - 1290, XP009121702, ISSN: 1350-0872
VIPOND C ET AL: "Characterization of the protein content of a meningococcal outer membrane vesicle vaccine by polyacrylamide gel electrophoresis and mass spectrometry", HUMAN VACCINES, LANDES BIOSCIENCE, GEORGETOWN, TX, US, vol. 1, no. 2, 1 January 2005 (2005-01-01), pages 80 - 84, XP008085859, ISSN: 1554-8600
STORK MICHIEL ET AL: "An Outer Membrane Receptor of Neisseria meningitidis Involved in Zinc Acquisition with Vaccine Potential", PLOS PATHOGENS, PUBLIC LIBRARY OF SCIENCE, SAN FRANCISCO, CA, US, vol. 6, no. 7, 1 July 2010 (2010-07-01), pages E1000969 - 1, XP009148766, ISSN: 1553-7366
Attorney, Agent or Firm:
WHITAKER, Duncan, Andrew (Global Patents 980 Great West Road, Brentford Middlesex TW8 9GS, GB)
Download PDF:
Previous Patent: PLASMA SUPPLY ARRANGEMENT WITH A QUADRATURE COUPLER
Next Patent: REMOVABLE KICK PANEL FOR A HOUSEHOLD APPLIANCE
Next Patent: REMOVABLE KICK PANEL FOR A HOUSEHOLD APPLIANCE