Title:
INFECTIOUS BOVINE RHINOTRACHEITIS VIRUS MUTANTS AND VACCINES
Document Type and Number:
WIPO Patent Application WO1994000586
Kind Code:
A3
Abstract:
A recombinant virus is provided which is obtained from a BHV virus originally having the gI gene whose DNA sequence is delimited by nucleotides 172 and 1311 of SEQ ID NO:1 herein and which has been mutated by total or partial deletion and/or insertion in this region. By the mutation in this region, there is no longer any expression of the glycoprotein which has been mutated or rendered inactive, and thus animals vaccinated with these mutants do not develop antibodies against the glycoprotein and can be serologically distinguished from animals infected by field BHV-1 strains and other vaccinal strains currently used. A method of using the present recombinant virus is also provided which allows one to distinguish infected animals from vaccinated animals in a manner that has not previously been possible using presently available commercial vaccines. The invention is thus advantageous in that the mutant viruses obtained by the invention can be used as vectors for expression of various foreign genes so as to prepare useful vaccines against bovine and ruminant diseases.
Inventors:
LEUNG-TACK PATRICIA (FR)
LEGASTELOIS ISABELLE CHRISTINE (FR)
AUDONNET JEAN-CHRISTOPHE FRANC (FR)
RIVIERE MICHEL EMILE ALBERT (FR)
LEGASTELOIS ISABELLE CHRISTINE (FR)
AUDONNET JEAN-CHRISTOPHE FRANC (FR)
RIVIERE MICHEL EMILE ALBERT (FR)
Application Number:
PCT/FR1993/000642
Publication Date:
February 17, 1994
Filing Date:
June 25, 1993
Export Citation:
Assignee:
RHONE MERIEUX (FR)
International Classes:
A61K39/245; A61P31/12; C07K14/06; C12N15/38; C12N15/869; A61K39/00; (IPC1-7): C12N15/86; C07K15/00
Domestic Patent References:
| WO1987004463A1 | 1987-07-30 | |||
| WO1987002058A1 | 1987-04-09 |
Foreign References:
| EP0316658A1 | 1989-05-24 | |||
| EP0431668A1 | 1991-06-12 | |||
| EP0326127A2 | 1989-08-02 | |||
| EP0256677A2 | 1988-02-24 |
Other References:
JOURNAL OF GENERAL VIROLOGY, vol. 71, 1990, pages 2969-2978, Reading, Berks, GB, J.-C, AUDONNET et al.: "Equine herpesvirus type 1 unique short fragment encodes glycoproteins with homology to herpes simplex virus type 1 gD, gI and gE", le document en entier (cité dans la demande)
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