INHIBITOR FOR 20-HETE-YIELDING ENZYME - TAISHO PHARMACEUTICAL CO LTD

Title:

INHIBITOR FOR 20-HETE-YIELDING ENZYME

Document Type and Number:

WIPO Patent Application WO/2001/032164

Kind Code:

A1

Abstract:

An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular diseases, or circulatory diseases. The novel hydroxyformamidine derivative or pharmacologically acceptable salt thereof is also provided.

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Inventors:

SATO MASAKAZU (JP)
MIYATA NORIYUKI (JP)
ISHII TAKAAKI (JP)
KOBAYASHI YUKO (JP)
AMADA HIDEAKI (JP)

Application Number:

PCT/JP2000/007694

Publication Date:

May 10, 2001

Filing Date:

November 01, 2000

Export Citation:

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Assignee:

TAISHO PHARMACEUTICAL CO LTD (JP)
SATO MASAKAZU (JP)
MIYATA NORIYUKI (JP)
ISHII TAKAAKI (JP)
KOBAYASHI YUKO (JP)
AMADA HIDEAKI (JP)

International Classes:

A61K31/155; A61K31/166; A61K31/18; A61K31/245; A61K31/275; A61K31/341; A61K31/343; A61K31/351; A61K31/352; A61K31/357; A61K31/36; A61K31/381; A61K31/40; A61K31/403; A61K31/4035; A61K31/404; A61K31/415; A61K31/416; A61K31/4192; A61K31/42; A61K31/4245; A61K31/426; A61K31/428; A61K31/429; A61K31/433; A61K31/44; A61K31/4402; A61K31/445; A61K31/4453; A61K31/45; A61K31/472; A61K31/502; A61K31/505; A61K31/522; A61K31/5375; C07C311/21; C07C311/46; C07C317/40; C07C323/12; C07C323/19; C07C323/41; C07C323/52; C07C323/65; C07C335/26; (IPC1-7): A61K31/155; A61K31/245; A61K31/18; A61K31/275; A61K31/166; A61K31/502; A61K31/36; A61K31/4035; A61K31/42; A61K31/429; A61K31/505; A61K31/403; A61K31/416; A61K31/4192; A61K31/404; A61K31/4245; A61K31/415; A61K31/519; A61K31/428; A61K31/352; A61K31/4453; A61K31/40; A61K31/343; A61K31/433; A61K31/472; A61K31/47; A61K31/5375; A61K31/381; A61K31/44; A61K31/45; A61K31/351; A61K31/341; A61K31/357; A61K31/426; A61K31/445; A61K31/4402; A61K31/522; C07C317/40; C07C323/65; C07C323/12; C07C323/19; C07C323/41

Foreign References:

JPS53132529A	1978-11-18
EP0132881A1	1985-02-13

Other References:

KOICHI HAYAKAWA ET AL.: "Quantitative structure-activity relationships of fungicidal N-phenylformamidoximes", JOURNAL OF PESTICIDE SCIENCE, vol. 17, no. 1, 1992, pages 17 - 25, XP002936344
MAGDELENA ALONSO-GALICIA ET AL.: "Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide", HYPERTENSION, vol. 29, no. 1(2), 1997, pages 320 - 325, XP002936345
See also references of EP 1226819A4

Attorney, Agent or Firm:

Shiga, Masatake (Takadanobaba 3-chome Shinjuku-ku Tokyo, JP)

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