Title:
INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN
Document Type and Number:
WIPO Patent Application WO/2001/098493
Kind Code:
A1
Abstract:
A protein, a DNA encoding this protein and an antibody recognizing this protein. Use of these substances makes it possible to provide a method of judging diseases relating to the novel insulin-like growth factor-binding protein, and diagnostics, preventives and remedies for diseases relating to the above-described protein.
Inventors:
YAMANO KAZUYA (JP)
SEKINE SUSUMU (JP)
SATOH MITSUO (JP)
OTA TOSHIO (JP)
FURUYA AKIKO (JP)
SHIBATA KENJI (US)
KOBAYASHI YUKI (JP)
TAKEBAYASHI MIHO (JP)
NAKAMURA YUSUKE (JP)
SUGANO SUMIO (JP)
SEKINE SUSUMU (JP)
SATOH MITSUO (JP)
OTA TOSHIO (JP)
FURUYA AKIKO (JP)
SHIBATA KENJI (US)
KOBAYASHI YUKI (JP)
TAKEBAYASHI MIHO (JP)
NAKAMURA YUSUKE (JP)
SUGANO SUMIO (JP)
Application Number:
PCT/JP2001/005112
Publication Date:
December 27, 2001
Filing Date:
June 15, 2001
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
YAMANO KAZUYA (JP)
SEKINE SUSUMU (JP)
SATOH MITSUO (JP)
OTA TOSHIO (JP)
FURUYA AKIKO (JP)
SHIBATA KENJI (US)
KOBAYASHI YUKI (JP)
TAKEBAYASHI MIHO (JP)
NAKAMURA YUSUKE (JP)
SUGANO SUMIO (JP)
YAMANO KAZUYA (JP)
SEKINE SUSUMU (JP)
SATOH MITSUO (JP)
OTA TOSHIO (JP)
FURUYA AKIKO (JP)
SHIBATA KENJI (US)
KOBAYASHI YUKI (JP)
TAKEBAYASHI MIHO (JP)
NAKAMURA YUSUKE (JP)
SUGANO SUMIO (JP)
International Classes:
A61P1/04; A61P3/06; A61P3/10; A61P3/14; A61P5/00; A61P7/02; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P13/12; A61P19/10; A61P27/02; A61P29/00; A61P35/00; A61P35/02; C07K14/47; C07K16/18; C07K16/26; C12N1/15; C12N1/19; C12N1/21; C12N15/12; C12P21/08; A61K38/00; (IPC1-7): C12N15/12; A01K67/027; A61K31/7088; A61K31/711; A61K38/17; A61K39/395; A61K48/00; A61P1/04; A61P3/06; A61P3/10; A61P3/14; A61P5/00; A61P7/02; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P13/12; A61P19/10; A61P27/02; A61P29/00; A61P35/00; A61P35/02; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/00; C12P21/02; C12P21/08; C12Q1/68; G01N33/15; G01N33/50; G01N33/53
Domestic Patent References:
| WO2000036105A1 | 2000-06-22 |
Foreign References:
| JPS58110600A | 1983-07-01 | |||
| JPS60221091A | 1985-11-05 | |||
| US4686191A | 1987-08-11 | |||
| US4939094A | 1990-07-03 | |||
| US5160735A | 1992-11-03 |
Other References:
YAMAUCHI T. ET AL.: "Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells", BIOCHEM. J., vol. 303, no. 2, 15 October 1994 (1994-10-15), pages 591 - 598, XP002945829
MURPHY M. ET AL.: "Identification and characterization of genes differentially expressed in meningiomas", CELL GROWTH DIFFER., vol. 4, no. 9, September 1993 (1993-09-01), pages 715 - 722, XP002945830
SWISSHELM K. ET AL.: "Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid", PROC. NATL. ACAD. SCI. USA, vol. 92, no. 10, 9 May 1995 (1995-05-09), pages 4472 - 4476, XP002945831
See also references of EP 1295939A4
METHODS IN ENZYMOLOGY, vol. 154, 1987, pages 3
ANALYTICAL BIOCHEMISTRY, vol. 162, 1987, pages 156
EXPERIMENTAL MEDICINE, vol. 9, 1991, pages 1937
"Molecular Cloning"
AGRIC. BIOL. CHEM., vol. 48, 1984, pages 669
AGRIC. BIOL. CHEM., vol. 53, 1989, pages 277
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 4306
J. BACTERIOL., vol. 172, 1990, pages 2392
MURPHY M. ET AL.: "Identification and characterization of genes differentially expressed in meningiomas", CELL GROWTH DIFFER., vol. 4, no. 9, September 1993 (1993-09-01), pages 715 - 722, XP002945830
SWISSHELM K. ET AL.: "Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid", PROC. NATL. ACAD. SCI. USA, vol. 92, no. 10, 9 May 1995 (1995-05-09), pages 4472 - 4476, XP002945831
See also references of EP 1295939A4
METHODS IN ENZYMOLOGY, vol. 154, 1987, pages 3
ANALYTICAL BIOCHEMISTRY, vol. 162, 1987, pages 156
EXPERIMENTAL MEDICINE, vol. 9, 1991, pages 1937
"Molecular Cloning"
AGRIC. BIOL. CHEM., vol. 48, 1984, pages 669
AGRIC. BIOL. CHEM., vol. 53, 1989, pages 277
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 4306
J. BACTERIOL., vol. 172, 1990, pages 2392
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