Title:
ISONIAZID DRY POWDER INHALANT FOR TREATING PULMONARY TUBERCULOSIS
Document Type and Number:
WIPO Patent Application WO/2022/116792
Kind Code:
A1
Abstract:
An isoniazid dry powder inhalant for treating pulmonary tuberculosis, having high stability, containing an isoniazid micro-powder, and containing or not containing a carrier micro-powder. The particle size of the isoniazid micro-powder is processed to 0.1-10 μm by means of a fluidized bed supersonic jet milling method or a spray drying method. Preferably, an adjuvant such as leucine, mannitol, or phospholipid can be added into the dry powder inhalant to improve the granulation rate of the particles, and an adjuvant such as magnesium stearate, mannitol, leucine, and/or lactose are additionally added to improve the fluidity of the drug and reduce particle agglomeration. The dry powder inhalant is suitable for treating pulmonary tuberculosis patients with liver dysfunction.
Inventors:
ZHANG TONGTONG (CN)
WANG SHIQIANG (CN)
QU WEI (CN)
ZHANG TAO (CN)
ZHANG GUOLI (CN)
YAN XIEGUO (CN)
LI YONG (CN)
LIANG MINCAI (CN)
WANG SHIQIANG (CN)
QU WEI (CN)
ZHANG TAO (CN)
ZHANG GUOLI (CN)
YAN XIEGUO (CN)
LI YONG (CN)
LIANG MINCAI (CN)
Application Number:
PCT/CN2021/130116
Publication Date:
June 09, 2022
Filing Date:
November 11, 2021
Export Citation:
Assignee:
SHENZHEN SCIENCARE MEDICAL IND CO LTD (CN)
International Classes:
A61K31/4409; A61K9/72; A61K47/12; A61K47/26; A61P31/06
Foreign References:
| CN112336703A | 2021-02-09 | |||
| CN106692116A | 2017-05-24 | |||
| CN103110633A | 2013-05-22 | |||
| CN101422457A | 2009-05-06 |
Other References:
SIBUM IMCO, HAGEDOORN PAUL, FRIJLINK HENDERIK W., GRASMEIJER FLORIS: "Characterization and Formulation of Isoniazid for High-Dose Dry Powder Inhalation", PHARMACEUTICS, vol. 11, no. 5, 1 January 2019 (2019-01-01), pages 1 - 15, XP055935987, DOI: 10.3390/pharmaceutics11050233
LIANG CHAOFENG , LU KEWEI , LUO HUIHONG , LIU YING , SU SHINA , GUANGDONG LINGNAN: "Research Progress of Dry Powder Inhalant", PHARMACY TODAY, vol. 29, no. 4, 3 April 2019 (2019-04-03), pages 283 - 288, XP055935991, ISSN: 1674-229X, DOI: 10.12048/j.issn.1674-229X.2019.04.017
LIANG CHAOFENG , LU KEWEI , LUO HUIHONG , LIU YING , SU SHINA , GUANGDONG LINGNAN: "Research Progress of Dry Powder Inhalant", PHARMACY TODAY, vol. 29, no. 4, 3 April 2019 (2019-04-03), pages 283 - 288, XP055935991, ISSN: 1674-229X, DOI: 10.12048/j.issn.1674-229X.2019.04.017
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