Title:
ISOPROPYLMALATE SYNTHASE VARIANT AND METHOD FOR PRODUCING L-LEUCINE BY USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/186487
Kind Code:
A1
Abstract:
The present application relates to a modified isopropylmalate synthase variant and a method for producing L-leucine by using same.
Inventors:
LEE HAYUN (KR)
KIM JU EUN (KR)
LEE JI HYE (KR)
KIM JU EUN (KR)
LEE JI HYE (KR)
Application Number:
PCT/KR2022/001560
Publication Date:
September 09, 2022
Filing Date:
January 28, 2022
Export Citation:
Assignee:
CJ CHEILJEDANG CORP (KR)
International Classes:
C12N9/10; C12N15/77; C12P13/06
Domestic Patent References:
| WO2021187781A1 | 2021-09-23 | |||
| WO2021112469A1 | 2021-06-10 |
Foreign References:
| KR20180077008A | 2018-07-06 | |||
| EP1568776A2 | 2005-08-31 | |||
| KR20140067082A | 2014-06-03 | |||
| EP2841568A1 | 2015-03-04 | |||
| KR100220018B1 | 1999-10-01 | |||
| KR100438146B1 | 2004-11-03 | |||
| US20150079641A1 | 2015-03-19 | |||
| US6403342B1 | 2002-06-11 | |||
| US7662943B2 | 2010-02-16 | |||
| US10584338B2 | 2020-03-10 | |||
| US10273491B2 | 2019-04-30 | |||
| US20210254111A1 | 2021-08-19 |
Other References:
KOHLHAW GUNTER B.: "Leucine Biosynthesis in Fungi: Entering Metabolism through the Back Door", MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 67, no. 1, 1 March 2003 (2003-03-01), US , pages 1 - 15, XP055963417, ISSN: 1092-2172, DOI: 10.1128/MMBR.67.1.1-15.2003
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
RICE ET AL.: "EMBOSS: The European Molecular Biology Open Software Suite", TRENDS GENET., vol. 16, 2000, pages 276 - 277, XP004200114, DOI: 10.1016/S0168-9525(00)02024-2
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444
DEVEREUX, J. ET AL., NUCLEIC ACIDS RESEARCH, vol. 12, 1984, pages 387
BLASTP, BLASTN, FASTA, ATSCHUL, S. F., J MOLEC BIOL 215, vol. 403, 1990
"Guide to Huge Computers", 1994, ACADEMIC PRESS
CARILLO ET AL., SIAM J APPLIED MATH, vol. 48, 1988, pages 1073
NEEDLEMAN ET AL., J MOL BIOL., vol. 48, 1970, pages 443
SMITHWATERMAN, ADV. APPL. MATH, vol. 2, 1981, pages 482
GRIBSKOV ET AL., NUCL. ACIDS RES., vol. 14, 1986, pages 6745
"National Biomedical Research Foundation", 1979, article "Atlas Of Protein Sequence And Structure", pages: 353 - 358
J. SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SITNICKA ET AL., FUNCTIONAL ANALYSIS OF GENES. ADVANCES IN CELL BIOLOGY., vol. 2, 2010, pages 1 - 16
SAMBROOK ET AL., MOLECULAR CLONING, 2012
"Manual of Methods for General Bacteriology", AMERICAN SOCIETY FOR BACTERIOLOGY, 1981
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
RICE ET AL.: "EMBOSS: The European Molecular Biology Open Software Suite", TRENDS GENET., vol. 16, 2000, pages 276 - 277, XP004200114, DOI: 10.1016/S0168-9525(00)02024-2
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444
DEVEREUX, J. ET AL., NUCLEIC ACIDS RESEARCH, vol. 12, 1984, pages 387
BLASTP, BLASTN, FASTA, ATSCHUL, S. F., J MOLEC BIOL 215, vol. 403, 1990
"Guide to Huge Computers", 1994, ACADEMIC PRESS
CARILLO ET AL., SIAM J APPLIED MATH, vol. 48, 1988, pages 1073
NEEDLEMAN ET AL., J MOL BIOL., vol. 48, 1970, pages 443
SMITHWATERMAN, ADV. APPL. MATH, vol. 2, 1981, pages 482
GRIBSKOV ET AL., NUCL. ACIDS RES., vol. 14, 1986, pages 6745
"National Biomedical Research Foundation", 1979, article "Atlas Of Protein Sequence And Structure", pages: 353 - 358
J. SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SITNICKA ET AL., FUNCTIONAL ANALYSIS OF GENES. ADVANCES IN CELL BIOLOGY., vol. 2, 2010, pages 1 - 16
SAMBROOK ET AL., MOLECULAR CLONING, 2012
"Manual of Methods for General Bacteriology", AMERICAN SOCIETY FOR BACTERIOLOGY, 1981
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY AND LAW (KR)
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