Title:
LASER DESORPTION AND IONIZATION MASS SPECTROMETER WITH QUANTITATIVE REPRODUCIBILITY
Document Type and Number:
WIPO Patent Application WO2006009904
Kind Code:
A3
Abstract:
Laser desorption/ionization time-of-flight mass spectrometer ("LDI-TOF-MS") devices, and methods, that accurately measure the mass of analytes contained in a sample and which also measure the quantities of analytes present in a sample in a consistent manner from instrument-to-instrument and over time on a single instrument. In particular, the invention provides LDI-TOF-MS devices and methods in which: 1) the energy of the laser pulse and the area of the sample illuminated (fluence) is consistent and controlled so as to produce consistent conditions for analyte desorption and ionization; 2) the mass analyzer behaves in a reproducible manner; and 3) the detection system produces a signal that consistently represents the arrival of ions of different masses.
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Inventors:
YOUNGQUIST MICHAEL G (US)
KELLER CRAIG A (US)
KELLER CRAIG A (US)
Application Number:
PCT/US2005/021584
Publication Date:
September 14, 2006
Filing Date:
June 17, 2005
Export Citation:
Assignee:
CIPHERGEN BIOSYSTEMS INC (US)
YOUNGQUIST MICHAEL G (US)
KELLER CRAIG A (US)
YOUNGQUIST MICHAEL G (US)
KELLER CRAIG A (US)
International Classes:
B01D59/44; H01J49/16
Foreign References:
| US6580070B2 | 2003-06-17 | |||
| US20040108451A1 | 2004-06-10 | |||
| US20050017174A1 | 2005-01-27 | |||
| US20050056776A1 | 2005-03-17 | |||
| US20050230612A1 | 2005-10-20 | |||
| US20050279929A1 | 2005-12-22 |
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