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Title:
LINEAR MAMMALIAN ARTIFICIAL CHROMOSOME AND METHOD OF CONSTRUCTING THE SAME
Document Type and Number:
WIPO Patent Application WO/2006/080248
Kind Code:
A1
Abstract:
It is intended to provide an artificial chromosome which is transmitted in a stable state from one generation to the next. A linear mammalian artificial chromosome is constructed by: (1) constructing a circular mammalian artificial chromosome having an insertion site; and (2) inserting a DNA construct containing a telomere sequence into the insertion site.

Inventors:
OKAZAKI TSUNEKO (JP)
IKENO MASASHI (JP)
SUZUKI NOBUTAKA (JP)
Application Number:
PCT/JP2006/300830
Publication Date:
August 03, 2006
Filing Date:
January 20, 2006
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Assignee:
OKAZAKI TSUNEKO (JP)
IKENO MASASHI (JP)
SUZUKI NOBUTAKA (JP)
International Classes:
C12N15/00; C12N5/10; C12N15/09; A61K48/00
Domestic Patent References:
WO2004022741A12004-03-18
WO2004031385A12004-04-15
Other References:
KATOH M. ET AL.: "Construction of a novel human artificial chromosome vector for gene delivery", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 321, no. 2, 2004, pages 280 - 290, XP004522500
IKENO M. ET AL.: "Construction of YAC-based mammalian artificial chromosomes", NAT. BIOTECHNOL., vol. 16, no. 5, 1998, pages 431 - 439, XP009060040
IKENO M. ET AL.: "Hito Jinko Senshokutai o Riyo shita Senshokutai Kino Ryoiki no Kaiseki", ANNUAL MEETING OF THE MOLECULAR BIOLOGY SCIENTY OF JAPAN KOEN YOSHISHU, DAI 28 KAI, 25 November 2005 (2005-11-25), pages 99, W4B-9, XP003004534
Attorney, Agent or Firm:
Konishi, Tomimasa (17-12 Marunouchi 2-chome, Naka-k, Nagoya-shi Aichi 02, JP)
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