Title:
A LIVE BACTERIA STRAIN OF PSEUDOMONAS SP.
Document Type and Number:
WIPO Patent Application WO/2024/002335
Kind Code:
A1
Abstract:
Provided is a live bacteria strain of a species from Pseudomonas sp. such as Pseudomonas aeruginosa and uses thereof. More particularly, provided is a live bacteria strain of P.aeruginosa with reduced OprF activity, to a vaccine against P. aeruginosa infection comprising said live bacteria strain, and to a method for preventing and/or treating P.aeruginosa infection in a subject by administering said live bacteria strain.
Inventors:
LIN QIUBIN (CN)
ZHANG MENGYA (CN)
SUN SHAOQI (CN)
LEE MING-CHUN (CN)
ZHANG MENGYA (CN)
SUN SHAOQI (CN)
LEE MING-CHUN (CN)
Application Number:
PCT/CN2023/104598
Publication Date:
January 04, 2024
Filing Date:
June 30, 2023
Export Citation:
Assignee:
SHANGHAI YUGUAN BIOTECH CO LTD (CN)
International Classes:
C12N1/20; A61K39/104; C12R1/385
Domestic Patent References:
| WO2007053194A2 | 2007-05-10 |
Foreign References:
| US20200023052A1 | 2020-01-23 |
Other References:
FITO-BONCOMPTE LAURÈNE, CHAPALAIN ANNELISE, BOUFFARTIGUES EMELINE, CHAKER HICHEM, LESOUHAITIER OLIVIER, GICQUEL GWENDOLINE, BAZIR: "Full Virulence of Pseudomonas aeruginosa Requires OprF", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 79, no. 3, 1 March 2011 (2011-03-01), US , pages 1176 - 1186, XP093125008, ISSN: 0019-9567, DOI: 10.1128/IAI.00850-10
MOUSSOUNI MALIKA, BERRY LAURENCE, SIPKA TAMARA, NGUYEN-CHI MAI, BLANC-POTARD ANNE-BÉATRICE: "Pseudomonas aeruginosa OprF plays a role in resistance to macrophage clearance during acute infection", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 11, no. 1, US , XP093125010, ISSN: 2045-2322, DOI: 10.1038/s41598-020-79678-0
AZGHANI, A.O. IDELL, S. BAINS, M. HANCOCK, R.E.W.: "Pseudomonas aeruginosa outer membrane protein F is an adhesin in bacterial binding to lung epithelial cells in culture", MICROBIAL PATHOGENESIS, ACADEMIC PRESS LIMITED, NEW YORK, NY., US, vol. 33, no. 3, 1 September 2002 (2002-09-01), US , pages 109 - 114, XP004796795, ISSN: 0882-4010, DOI: 10.1006/mpat.2002.0514
BUKHARI, S.I. ET AL.: "Association of OprF mutant and disturbance of biofilm and pyocyanin virulence in pseudomonas aeruginosa", SAUDI PHARMACEUTICAL JOURNAL, vol. 28, 7 December 2019 (2019-12-07), XP085987231, DOI: 10.1016/j.jsps.2019.11.021
WOODRUFF W A, HANCOCK R E: "Construction and characterization of Pseudomonas aeruginosa protein F-deficient mutants after in vitro and in vivo insertion mutagenesis of the cloned gene", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 170, no. 6, 1 June 1988 (1988-06-01), US , pages 2592 - 2598, XP093125030, ISSN: 0021-9193, DOI: 10.1128/jb.170.6.2592-2598.1988
BOUFFARTIGUES EMELINE, MOSCOSO JOANA A., DUCHESNE RACHEL, ROSAY THIBAUT, FITO-BONCOMPTE LAURÈNE, GICQUEL GWENDOLINE, MAILLOT OLIVI: "The absence of the Pseudomonas aeruginosa OprF protein leads to increased biofilm formation through variation in c-di-GMP level", FRONTIERS IN MICROBIOLOGY, FRONTIERS MEDIA, LAUSANNE, vol. 6, Lausanne , XP093125034, ISSN: 1664-302X, DOI: 10.3389/fmicb.2015.00630
GOTOH N, WAKEBE H, YOSHIHARA E, NAKAE T, NISHINO T: "Role of protein F in maintaining structural integrity of the Pseudomonas aeruginosa outer membrane", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 171, no. 2, 1 February 1989 (1989-02-01), US , pages 983 - 990, XP093125037, ISSN: 0021-9193, DOI: 10.1128/jb.171.2.983-990.1989
GOTOH N, WAKEBE H, YOSHIHARA E, NAKAE T, NISHINO T: "Role of protein F in maintaining structural integrity of the Pseudomonas aeruginosa outer membrane", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 171, no. 2, 1 February 1989 (1989-02-01), US , pages 983 - 990, XP093125037, ISSN: 0021-9193, DOI: 10.1128/jb.171.2.983-990.1989
MOUSSOUNI MALIKA, BERRY LAURENCE, SIPKA TAMARA, NGUYEN-CHI MAI, BLANC-POTARD ANNE-BÉATRICE: "Pseudomonas aeruginosa OprF plays a role in resistance to macrophage clearance during acute infection", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 11, no. 1, US , XP093125010, ISSN: 2045-2322, DOI: 10.1038/s41598-020-79678-0
AZGHANI, A.O. IDELL, S. BAINS, M. HANCOCK, R.E.W.: "Pseudomonas aeruginosa outer membrane protein F is an adhesin in bacterial binding to lung epithelial cells in culture", MICROBIAL PATHOGENESIS, ACADEMIC PRESS LIMITED, NEW YORK, NY., US, vol. 33, no. 3, 1 September 2002 (2002-09-01), US , pages 109 - 114, XP004796795, ISSN: 0882-4010, DOI: 10.1006/mpat.2002.0514
BUKHARI, S.I. ET AL.: "Association of OprF mutant and disturbance of biofilm and pyocyanin virulence in pseudomonas aeruginosa", SAUDI PHARMACEUTICAL JOURNAL, vol. 28, 7 December 2019 (2019-12-07), XP085987231, DOI: 10.1016/j.jsps.2019.11.021
WOODRUFF W A, HANCOCK R E: "Construction and characterization of Pseudomonas aeruginosa protein F-deficient mutants after in vitro and in vivo insertion mutagenesis of the cloned gene", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 170, no. 6, 1 June 1988 (1988-06-01), US , pages 2592 - 2598, XP093125030, ISSN: 0021-9193, DOI: 10.1128/jb.170.6.2592-2598.1988
BOUFFARTIGUES EMELINE, MOSCOSO JOANA A., DUCHESNE RACHEL, ROSAY THIBAUT, FITO-BONCOMPTE LAURÈNE, GICQUEL GWENDOLINE, MAILLOT OLIVI: "The absence of the Pseudomonas aeruginosa OprF protein leads to increased biofilm formation through variation in c-di-GMP level", FRONTIERS IN MICROBIOLOGY, FRONTIERS MEDIA, LAUSANNE, vol. 6, Lausanne , XP093125034, ISSN: 1664-302X, DOI: 10.3389/fmicb.2015.00630
GOTOH N, WAKEBE H, YOSHIHARA E, NAKAE T, NISHINO T: "Role of protein F in maintaining structural integrity of the Pseudomonas aeruginosa outer membrane", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 171, no. 2, 1 February 1989 (1989-02-01), US , pages 983 - 990, XP093125037, ISSN: 0021-9193, DOI: 10.1128/jb.171.2.983-990.1989
GOTOH N, WAKEBE H, YOSHIHARA E, NAKAE T, NISHINO T: "Role of protein F in maintaining structural integrity of the Pseudomonas aeruginosa outer membrane", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 171, no. 2, 1 February 1989 (1989-02-01), US , pages 983 - 990, XP093125037, ISSN: 0021-9193, DOI: 10.1128/jb.171.2.983-990.1989
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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