Title:
A LIVE STRAIN OF STAPHYLOCOCCUS AUREUS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/233420
Kind Code:
A1
Abstract:
In the field of biomedicine. In particular, provided are a live strain of staphylococcus aureus and uses thereof. More particularly, provided a live strain of Staphylococcus aureus which lacks adenosine synthase A (AdsA) activity, to a vaccine against Staphylococcus aureus infection comprising said live strain, and a method for preventing and/or treating Staphylococcus aureus infection in a subject by administering said live strain.
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Inventors:
HUANG JIANDONG (CN)
YUEN KWOKYUNG (CN)
ZHANG BAOZHONG (CN)
DENG JIAN (CN)
CHU HIN (CN)
YUEN KWOKYUNG (CN)
ZHANG BAOZHONG (CN)
DENG JIAN (CN)
CHU HIN (CN)
Application Number:
PCT/CN2021/095165
Publication Date:
November 25, 2021
Filing Date:
May 21, 2021
Export Citation:
Assignee:
VERSITECH LTD (CN)
International Classes:
C12N1/04; A61K35/74; A61P31/04; C12N1/21
Domestic Patent References:
| WO2019033007A2 | 2019-02-14 |
Foreign References:
| CN102333540A | 2012-01-25 | |||
| CN104098693A | 2014-10-15 |
Other References:
PERNET ERWAN, BRUNET JÉRÉMY, GUILLEMOT LAURENT, CHIGNARD MICHEL, TOUQUI LHOUSSEINE, WU YONGZHENG: "Staphylococcus aureus Adenosine Inhibits sPLA2-IIA–Mediated Host Killing in the Airways", THE JOURNAL OF IMMUNOLOGY, vol. 194, no. 11, 1 June 2015 (2015-06-01), Williams & Wilkins Co., US, pages 5312 - 5319, XP055874620, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1402665
HWAN KEUN KIM; VILASACK THAMMAVONGSA; OLAF SCHNEEWIND; DOMINIQUE MISSIAKAS;: "Recurrent infections and immune evasion strategies of", CURRENT OPINION IN MICROBIOLOGY, CURRENT BIOLOGY LTD, GB, vol. 15, no. 1, GB , pages 92 - 99, XP028450508, ISSN: 1369-5274, DOI: 10.1016/j.mib.2011.10.012
ARYA SMRITI, LIN QIUBIN, ZHOU NAN, GAO XIANG, HUANG JIAN-DONG: "Strong Immune Responses Induced by Direct Local Injections of Modified mRNA-Lipid Nanocomplexes", MOLECULAR THERAPY-NUCLEIC ACIDS,, vol. 19, 1 March 2020 (2020-03-01), Cell Press, US, pages 1098 - 1109, XP055874595, ISSN: 2162-2531, DOI: 10.1016/j.omtn.2019.12.044
ZHANG BAO-ZHONG, CAI JIANPIAO, YU BIN, XIONG LIFENG, LIN QIUBIN, YANG XIAO-YAN, XU CHEN, ZHENG SONGYUE, KAO RICHARD YI-TSUN, SZE K: "Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model", JOURNAL OF INFECTIOUS DISEASES, UNIVERSITY OF CHICAGO PRESS, US, vol. 216, no. 2, 15 July 2017 (2017-07-15), US , pages 245 - 253, XP055874589, ISSN: 0022-1899, DOI: 10.1093/infdis/jix290
HWAN KEUN KIM; VILASACK THAMMAVONGSA; OLAF SCHNEEWIND; DOMINIQUE MISSIAKAS;: "Recurrent infections and immune evasion strategies of", CURRENT OPINION IN MICROBIOLOGY, CURRENT BIOLOGY LTD, GB, vol. 15, no. 1, GB , pages 92 - 99, XP028450508, ISSN: 1369-5274, DOI: 10.1016/j.mib.2011.10.012
ARYA SMRITI, LIN QIUBIN, ZHOU NAN, GAO XIANG, HUANG JIAN-DONG: "Strong Immune Responses Induced by Direct Local Injections of Modified mRNA-Lipid Nanocomplexes", MOLECULAR THERAPY-NUCLEIC ACIDS,, vol. 19, 1 March 2020 (2020-03-01), Cell Press, US, pages 1098 - 1109, XP055874595, ISSN: 2162-2531, DOI: 10.1016/j.omtn.2019.12.044
ZHANG BAO-ZHONG, CAI JIANPIAO, YU BIN, XIONG LIFENG, LIN QIUBIN, YANG XIAO-YAN, XU CHEN, ZHENG SONGYUE, KAO RICHARD YI-TSUN, SZE K: "Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model", JOURNAL OF INFECTIOUS DISEASES, UNIVERSITY OF CHICAGO PRESS, US, vol. 216, no. 2, 15 July 2017 (2017-07-15), US , pages 245 - 253, XP055874589, ISSN: 0022-1899, DOI: 10.1093/infdis/jix290
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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