Title:
LYSOPHOSPHATIDIC ACID SYNTHASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2003/031615
Kind Code:
A1
Abstract:
A substance which inhibits the lysophosphatidic−acid−producing ability of a lysophosphatidic acid synthase. This substance is useful for diagnosing diseases attributable to the physiological activity of a lysophosphatidic acid, for mitigating symptoms attributable to the physiological activity of a lysophosphatidic acid, or for the prevention of or treatments for the diseases.
Inventors:
TOKUMURA AKIRA (JP)
MAJIMA EIJI (JP)
MAJIMA EIJI (JP)
Application Number:
PCT/JP2002/010342
Publication Date:
April 17, 2003
Filing Date:
October 03, 2002
Export Citation:
Assignee:
APRO LIFE SCIENCE INST INC (JP)
TOKUMURA AKIRA (JP)
MAJIMA EIJI (JP)
TOKUMURA AKIRA (JP)
MAJIMA EIJI (JP)
International Classes:
A61P9/10; A61P15/00; A61P35/00; A61P43/00; C12N9/00; C12Q1/48; (IPC1-7): C12N15/09; A61K39/395; A61K45/00; A61P9/10; A61P15/00; A61P35/00; A61P43/00; C07K16/40; C12N9/99; C12Q1/46; G01N33/15; G01N33/50
Domestic Patent References:
| WO1993014202A1 | 1993-07-22 | |||
| WO2000068386A1 | 2000-11-16 | |||
| WO2002053569A1 | 2002-07-11 |
Foreign References:
| JP2002017398A | 2002-01-22 |
Other References:
WYKLE R.L. ET AL.: "Specificity of lysophospholipase D", BIOCHIM. BIOPHYS. ACTA, vol. 619, 1980, pages 58 - 67, XP002966816
WYKLE R.L. ET AL.: "lysophospholipase D", METHODS ENZYMOL., vol. 197, 1991, pages 583 - 590, XP002966817
TOKUMURA A. ET AL.: "Metal-ion stimulation and inhibition of lysophospholipase D which generates bioactive lysophosphatidic acid in rat plasma", LIPIDS, vol. 33, no. 10, 1998, pages 1009 - 1015, XP002966818
TOKUMURA A. ET AL.: "Production of lysophosphatidic acids by lysophospholipase D in human follicular fluids of in vitro fertilization patients", BIOL. REPROD., vol. 61, no. 1, 1999, pages 195 - 199, XP002966819
WYKLE R.L. ET AL.: "lysophospholipase D", METHODS ENZYMOL., vol. 197, 1991, pages 583 - 590, XP002966817
TOKUMURA A. ET AL.: "Metal-ion stimulation and inhibition of lysophospholipase D which generates bioactive lysophosphatidic acid in rat plasma", LIPIDS, vol. 33, no. 10, 1998, pages 1009 - 1015, XP002966818
TOKUMURA A. ET AL.: "Production of lysophosphatidic acids by lysophospholipase D in human follicular fluids of in vitro fertilization patients", BIOL. REPROD., vol. 61, no. 1, 1999, pages 195 - 199, XP002966819
Attorney, Agent or Firm:
Iwatani, Ryo (1-27 Dojima 2-chome, Kita-k, Osaka-shi Osaka, JP)
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