Title:
MANUFACTURE OF LONG TERM DRUG DELIVERY DEVICES WITH POLYURETHANE BASED POLYMERS
Document Type and Number:
WIPO Patent Application WO2005013936
Kind Code:
A3
Abstract:
This invention is related to the use of polyurethane based polymer as a drug delivery device to deliver biologically active compounds at a constant rate for an extended period of time and methods of manufactures thereof. The device is very biocompatible and biostable, and is useful as an implant in patients (humans and animals) for the delivery of appropriate bioactive substances to tissues or organs. The drug delivery device for releasing one or more drugs at controlled rates for an extended period of time to produce local or systemic pharmacological effects comprises: 1. a reservoir, said reservoir comprising; 2. at least one active ingredient; and, optionally, 3. at least one pharmaceutically acceptable carrier; a polyurethane based polymer completely surrounding the reservoir.
Inventors:
KUO SHENG-HUNG (US)
KUZMA PETR (US)
KUZMA PETR (US)
Application Number:
PCT/IB2004/002823
Publication Date:
April 13, 2006
Filing Date:
August 11, 2004
Export Citation:
Assignee:
VALERA PHARMACEUTICALS INC (US)
KUO SHENG-HUNG (US)
KUZMA PETR (US)
KUO SHENG-HUNG (US)
KUZMA PETR (US)
International Classes:
A61F2/82; A61K9/00; A61K9/22; A61K9/26; A61K9/70; A61L27/18; A61L27/54; C08J5/00; (IPC1-7): A61K9/00
Foreign References:
| US5035891A | 1991-07-30 | |||
| US4469671A | 1984-09-04 | |||
| EP0200224A2 | 1986-11-05 | |||
| US4207890A | 1980-06-17 |
Other References:
ZONDERVAN G J ET AL: "DESIGN OF A POLYURETHANE MEMBRANE FOR THE ENCAPSULATION OF ISLETS OF LANGERHANS", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 13, no. 3, January 1992 (1992-01-01), pages 136 - 144, XP000258851, ISSN: 0142-9612
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