Title:
MARKER FOR DETERMINING CRITICAL STAGE KIDNEY DISEASE
Document Type and Number:
WIPO Patent Application WO/2020/080488
Kind Code:
A1
Abstract:
The present invention provides: a marker for determining critical stage kidney disease by using an indicator value based on the amount of D-alanine in the blood or the amount of D-alanine and L-alanine therein; a blood analysis method which uses said marker for patients undergoing surgery or intensive care; and a blood analysis system for determining critical stage kidney disease in patients undergoing surgery or intensive care.
Inventors:
MITA MASASHI (JP)
WADA TAKASHI (JP)
FURUICHI KENGO (JP)
SAKAI NORIHIKO (JP)
IWATA YASUNORI (JP)
KITAJIMA SHINJI (JP)
NAKADE YUSUKE (JP)
WADA TAKASHI (JP)
FURUICHI KENGO (JP)
SAKAI NORIHIKO (JP)
IWATA YASUNORI (JP)
KITAJIMA SHINJI (JP)
NAKADE YUSUKE (JP)
Application Number:
PCT/JP2019/040968
Publication Date:
April 23, 2020
Filing Date:
October 17, 2019
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
UNIV NAT CORP KANAZAWA (JP)
UNIV NAT CORP KANAZAWA (JP)
International Classes:
G01N33/68; G01N33/48; G01N33/70
Foreign References:
| JP2015132598A | 2015-07-23 |
Other References:
SUZUKI MASATAKA ET AL.: "Diseases and D-amino acids: potential as biomarkers", SEIBUTSU KOGAKU, vol. 92, 2014, pages 661 - 664
KIMURA, T. ET AL.: "Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease", SCIENTIFIC REPORTS, vol. 6, May 2016 (2016-05-01), pages 1 - 7, XP055371897
NAKADE, Y. ET AL.: "Gut microbiota-derived D-serine protects against acute kidney injury", JCI INSIGHT, vol. 3, no. 20, 18 October 2018 (2018-10-18), pages 1 - 16, XP055662467, DOI: 10.1172/jci.insight.97957
KIMURA, T. ET AL.: "Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease", SCIENTIFIC REPORTS, vol. 6, May 2016 (2016-05-01), pages 1 - 7, XP055371897
NAKADE, Y. ET AL.: "Gut microbiota-derived D-serine protects against acute kidney injury", JCI INSIGHT, vol. 3, no. 20, 18 October 2018 (2018-10-18), pages 1 - 16, XP055662467, DOI: 10.1172/jci.insight.97957
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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