Title:
MEDICAMENTS
Document Type and Number:
WIPO Patent Application WO1999017755
Kind Code:
A3
Abstract:
This invention relates to the use of 5-HT3 receptor antagonists in the treatment of nonconstipated female IBS patients.
Inventors:
MANGEL ALLEN WAYNE (US)
NORTHCUTT ALLISON RUTH (US)
NORTHCUTT ALLISON RUTH (US)
Application Number:
PCT/EP1998/006278
Publication Date:
September 23, 1999
Filing Date:
October 05, 1998
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
MANGEL ALLEN WAYNE (US)
NORTHCUTT ALLISON RUTH (US)
MANGEL ALLEN WAYNE (US)
NORTHCUTT ALLISON RUTH (US)
International Classes:
A61K31/00; A61K31/40; A61K31/435; A61K31/47; A61K31/495; A61K31/55; A61K45/00; A61P1/00; A61P1/08; A61P25/04; A61P43/00; (IPC1-7): A61K31/00; A61K31/435; A61K31/40; A61K31/47; A61K31/495; A61K31/55
Domestic Patent References:
| WO1992012149A1 | 1992-07-23 | |||
| WO1992011259A1 | 1992-07-09 | |||
| WO1992010494A1 | 1992-06-25 | |||
| WO1992005174A1 | 1992-04-02 | |||
| WO1989009217A1 | 1989-10-05 | |||
| WO1994001095A2 | 1994-01-20 |
Foreign References:
| EP0387431A1 | 1990-09-19 | |||
| EP0377967A2 | 1990-07-18 | |||
| EP0385722A2 | 1990-09-05 | |||
| EP0364274A1 | 1990-04-18 | |||
| EP0357416A2 | 1990-03-07 | |||
| EP0347229A1 | 1989-12-20 | |||
| EP0336759A1 | 1989-10-11 | |||
| EP0254584A2 | 1988-01-27 | |||
| EP0279512A2 | 1988-08-24 | |||
| EP0315390A2 | 1989-05-10 | |||
| EP0306323A2 | 1989-03-08 |
Other References:
K. BARDHAN ET AL.: "A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFOCACY OF ALOSETRON IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME (IBS)", GASTROENTEROLOGY, vol. 110, no. 4, April 1996 (1996-04-01), pages A630, XP002098634
J.M. FOSTER ET AL.: "ALOSETRON SLOWS COLONIC TRANSIT IN PATIENTS WITH IRRITABLE BOWEL SYNDROME (IBS)", GASTROENTEROLOGY, vol. 112, 11 May 1997 (1997-05-11) - 14 May 1997 (1997-05-14), pages A732, XP002098635
D.G.MAXTON ET AL.: "Selective 5-hydroxytryptamine antagonism: a role in irritable bowel syndrome and functional dyspepsia?", ALIMENT.PHARMACOL.THER., vol. 10, no. 4, August 1996 (1996-08-01), pages 595 - 599, XP002098636
J. ZIGHELBOIM ET AL.: "Visceral Perception in Irritable Bowel Syndrome", DIG.SIS.SCI., vol. 40, no. 4, April 1995 (1995-04-01), pages 819 - 827, XP002098637
C.J.STEADMAN ET AL.: "Selective 5-Hydroxytryptamine Type 3 Receptor Antagonism With Ondansetron as Treatment for Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Study", MAYO CLINIC PROC., vol. 67, no. 8, August 1992 (1992-08-01), pages 732 - 738, XP002098638
P.H.HSYU ET AL.: "SAFETY AND AGE, GENDER, AND TIME DEPENDENT PHARMACOKINETICS OF ALOSETRON", PHARMACEUTICAL RESEARCH, vol. 12, no. 9 Suppl., September 1995 (1995-09-01), pages S387, XP002098639
M. DELVAUX ET AL.: "Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome", ALIMENT.PHARMACOL.THER., vol. 12, no. 9, September 1998 (1998-09-01), pages 849 - 855, XP002098640
R.BERKOW ET AL., ED.: "THE MERCK MANUAL OF DIAGNOSIS AND THERAPY, 16th edition", 1992, MERCK RESEARCH LABORATORIES, RAHWAY, N.J., XP002098642
A.R.NORTHCUTT ET AL.: "ALOSETRON, A 5HT3-RECEPTOR ANTAGONIST, IS EFFECTIVE IN THE TREATMENT OF FEMALE IRRITABLE BOWEL SYNDROME PATIENTS", GASTROENTEROLOGY, vol. 114, no. 4 Part 2, April 1998 (1998-04-01), pages A812, XP002098641
J.M. FOSTER ET AL.: "ALOSETRON SLOWS COLONIC TRANSIT IN PATIENTS WITH IRRITABLE BOWEL SYNDROME (IBS)", GASTROENTEROLOGY, vol. 112, 11 May 1997 (1997-05-11) - 14 May 1997 (1997-05-14), pages A732, XP002098635
D.G.MAXTON ET AL.: "Selective 5-hydroxytryptamine antagonism: a role in irritable bowel syndrome and functional dyspepsia?", ALIMENT.PHARMACOL.THER., vol. 10, no. 4, August 1996 (1996-08-01), pages 595 - 599, XP002098636
J. ZIGHELBOIM ET AL.: "Visceral Perception in Irritable Bowel Syndrome", DIG.SIS.SCI., vol. 40, no. 4, April 1995 (1995-04-01), pages 819 - 827, XP002098637
C.J.STEADMAN ET AL.: "Selective 5-Hydroxytryptamine Type 3 Receptor Antagonism With Ondansetron as Treatment for Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Study", MAYO CLINIC PROC., vol. 67, no. 8, August 1992 (1992-08-01), pages 732 - 738, XP002098638
P.H.HSYU ET AL.: "SAFETY AND AGE, GENDER, AND TIME DEPENDENT PHARMACOKINETICS OF ALOSETRON", PHARMACEUTICAL RESEARCH, vol. 12, no. 9 Suppl., September 1995 (1995-09-01), pages S387, XP002098639
M. DELVAUX ET AL.: "Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome", ALIMENT.PHARMACOL.THER., vol. 12, no. 9, September 1998 (1998-09-01), pages 849 - 855, XP002098640
R.BERKOW ET AL., ED.: "THE MERCK MANUAL OF DIAGNOSIS AND THERAPY, 16th edition", 1992, MERCK RESEARCH LABORATORIES, RAHWAY, N.J., XP002098642
A.R.NORTHCUTT ET AL.: "ALOSETRON, A 5HT3-RECEPTOR ANTAGONIST, IS EFFECTIVE IN THE TREATMENT OF FEMALE IRRITABLE BOWEL SYNDROME PATIENTS", GASTROENTEROLOGY, vol. 114, no. 4 Part 2, April 1998 (1998-04-01), pages A812, XP002098641
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