MEDICINE COMPRISING COMBINATION OF FIVE−MEMBERED HETEROCYCLIC COMPOUND AND DRUG COMPENSATING FOR OR ENHANCING ITS ACTIVITY

Title:

MEDICINE COMPRISING COMBINATION OF FIVE−MEMBERED HETEROCYCLIC COMPOUND AND DRUG COMPENSATING FOR OR ENHANCING ITS ACTIVITY

Document Type and Number:

WIPO Patent Application WO/2003/006014

Kind Code:

A1

Abstract:

A medicine comprising a combination of a five−membered heterocyclic compound represented by the general formula (I) or pharmaceutically acceptable salt thereof with a drug which compensates for and&sol or enhances the remedial effect of the compound or salt [in the formula, Z represents an &agr −aminocarbonyl−containing group&semi R¹ represents (1) substituted alkyl, alkenyl, or alkynyl, (2) OH, (3) amino, (4) alkylamino, or (5) dialkylamino, etc.&semi and X and Y each represents oxygen, sulfur, or substituted nitrogen]. (I) The medicine, which comprises a combination of a five−membered heterocyclic compound represented by the general formula (I) or pharmaceutically acceptable salt thereof with a drug which compensates for and&sol or enhances the remedial effect of the compound or salt, is useful for the prevention of and&sol or treatments for various diseases.

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Inventors:

KAWABATA KAZUHITO (JP)

Application Number:

PCT/JP2002/006946

Publication Date:

January 23, 2003

Filing Date:

July 09, 2002

Export Citation:

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Assignee:

ONO PHARMACEUTICAL CO (JP)
KAWABATA KAZUHITO (JP)

International Classes:

A61K31/4245; A61K31/4439; A61K31/513; A61K31/5377; A61K31/55; A61K31/5513; A61P11/00; (IPC1-7): A61K31/4245; A61K31/4439; A61K31/513; A61K31/5377; A61K31/55; A61K31/5513; A61K38/00; A61K45/00; A61P11/00

Domestic Patent References:

WO1996016080A1	1996-05-30
WO1998024806A2	1998-06-11

Other References:

STOCKLEY R.A.: "New approaches to the management of COPD", CHEST, vol. 117, no. SUPPL. 2, 2000, pages 58S - 62S, XP002957644
FUJIE K. ET AL.: "Inhibition of alastase-induced acute inflammation and pulmonary emphysema in hamsters by a novel neutrophil elastase inhibitor FR901277", INFLAMM. RES., vol. 48, no. 3, 1999, pages 160 - 167, XP002957645
TAKEO ISHII ET AL.: "Yakubutsu ryoho no aratana tenkai", JAPANESE JORNAL OF CLINICAL MEDICINE, vol. 57, no. 9, 1999, pages 105 - 110, XP002960755

Attorney, Agent or Firm:

Ohie, Kunihisa (Horiguchi No.2 Bldg. 7F 2-6, Nihonbashi-Ningyocho, 2-chom, Chuo-ku Tokyo, JP)

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