Title:
MEDICINE CONTAINING USAG-1-TARGETING RNA MOLECULE FOR TOOTH REGENERATION THERAPY
Document Type and Number:
WIPO Patent Application WO/2021/167056
Kind Code:
A1
Abstract:
Provided is a medicinal composition to be topically administered for tooth regeneration therapy, said composition comprising an RNA molecule targeting USAG-1 or a nucleic acid molecule capable of yielding the RNA molecule and a pharmaceutically acceptable carrier.
Inventors:
TAKAHASHI KATSU (JP)
BESSHO KAZUHISA (JP)
TABATA YASUHIKO (JP)
SUGAI MANABU (JP)
TOKITA YOSHIHITO (JP)
BESSHO KAZUHISA (JP)
TABATA YASUHIKO (JP)
SUGAI MANABU (JP)
TOKITA YOSHIHITO (JP)
Application Number:
PCT/JP2021/006296
Publication Date:
August 26, 2021
Filing Date:
February 19, 2021
Export Citation:
Assignee:
UNIV KYOTO (JP)
UNIV FUKUI (JP)
AICHI PREFECTURE (JP)
UNIV FUKUI (JP)
AICHI PREFECTURE (JP)
International Classes:
A61K31/7105; A61K9/06; A61K47/42; A61P1/02; A61P19/08; A61P43/00; C12N15/113
Foreign References:
| JP2004155668A | 2004-06-03 | |||
| JP2003286200A | 2003-10-07 |
Other References:
TOGO YUMIKO, TAKAHASHI KATSU, SAITO KAZUYUKI, KISO HONOKA, TSUKAMOTO HIROKO, HUANG BOYEN, YANAGITA MOTOKO, SUGAI MANABU, HARADA HI: "Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development", PLOS ONE, vol. 11, no. 8, 12 August 2016 (2016-08-12), pages e0161067, XP055856039, DOI: 10.1371/journal.pone.0161067
DATABASE NUCLEOTIDE 24 June 2021 (2021-06-24), ANONYMOUS : "Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA", XP055856042, retrieved from NCBI Database accession no. NM_015464
KUSHIBIKI, T. ; NAGATA-NAKAJIMA, N. ; SUGAI, M. ; SHIMIZU, A. ; TABATA, Y.: "Delivery of plasmid DNA expressing small interference RNA for TGF-@b type II receptor by cationized gelatin to prevent interstitial renal fibrosis", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 105, no. 3, 20 July 2005 (2005-07-20), AMSTERDAM, NL , pages 318 - 331, XP027664223, ISSN: 0168-3659
TAKAHASHI KATSU, KISO HONOKA, MURASHIMA-SUGINAMI AKIKO, TOKITA YOSHIHITO, SUGAI MANABU, TABATA YASUHIKO, BESSHO KAZUHISA: "Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy", INFLAMMATION AND REGENERATION, vol. 40, no. 21, 1 September 2020 (2020-09-01), XP055856037, DOI: 10.1186/s41232-020-00130-x
OHAZAMA A. ET AL., J DENR RES, vol. 83, no. 7, July 2004 (2004-07-01), pages 518 - 22
NAKAO K. ET AL., NAT METHODS, vol. 4, no. 3, March 2007 (2007-03-01), pages 227 - 30
SAITO K ET AL., SCI. REP., 2018
J CONTROL RELEASE, vol. 105, no. 3, 20 July 2005 (2005-07-20), pages 318 - 31
DATABASE NUCLEOTIDE 24 June 2021 (2021-06-24), ANONYMOUS : "Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA", XP055856042, retrieved from NCBI Database accession no. NM_015464
KUSHIBIKI, T. ; NAGATA-NAKAJIMA, N. ; SUGAI, M. ; SHIMIZU, A. ; TABATA, Y.: "Delivery of plasmid DNA expressing small interference RNA for TGF-@b type II receptor by cationized gelatin to prevent interstitial renal fibrosis", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 105, no. 3, 20 July 2005 (2005-07-20), AMSTERDAM, NL , pages 318 - 331, XP027664223, ISSN: 0168-3659
TAKAHASHI KATSU, KISO HONOKA, MURASHIMA-SUGINAMI AKIKO, TOKITA YOSHIHITO, SUGAI MANABU, TABATA YASUHIKO, BESSHO KAZUHISA: "Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy", INFLAMMATION AND REGENERATION, vol. 40, no. 21, 1 September 2020 (2020-09-01), XP055856037, DOI: 10.1186/s41232-020-00130-x
OHAZAMA A. ET AL., J DENR RES, vol. 83, no. 7, July 2004 (2004-07-01), pages 518 - 22
NAKAO K. ET AL., NAT METHODS, vol. 4, no. 3, March 2007 (2007-03-01), pages 227 - 30
SAITO K ET AL., SCI. REP., 2018
J CONTROL RELEASE, vol. 105, no. 3, 20 July 2005 (2005-07-20), pages 318 - 31
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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