Title:
METALLOPROTEINASE-DISINTEGRIN POLYPEPTIDES AND METHODS OF MAKING AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO2002010406
Kind Code:
A3
Abstract:
Provided is a new disintegrin polypeptide, methods of making such polypeptides, and methods of using them to treat disintegrin-associated disorders and conditions and to identify agents that modulate Metalloproteinase-Disintegrin polypeptide activities.
Inventors:
DUBOSE ROBERT F (US)
WILEY STEVEN R (US)
BLACK ROY A (US)
WILEY STEVEN R (US)
BLACK ROY A (US)
Application Number:
PCT/US2001/023734
Publication Date:
January 16, 2003
Filing Date:
July 27, 2001
Export Citation:
Assignee:
IMMUNEX CORP (US)
DUBOSE ROBERT F (US)
WILEY STEVEN R (US)
BLACK ROY A (US)
DUBOSE ROBERT F (US)
WILEY STEVEN R (US)
BLACK ROY A (US)
International Classes:
G01N33/48; A61K38/00; A61P7/02; A61P9/10; A61P17/02; A61P19/10; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/07; C12N5/071; C12N5/077; C12N5/10; C12N9/64; C12N15/09; C12N15/57; C12P21/02; C12P21/08; G01N33/15; G01N33/50; G01N33/53; G01N33/566; G16B15/30; (IPC1-7): C12N15/57; C12N9/64; C07K16/40; G01N33/68; A61K38/43; G06F15/00; G06F19/00; C12Q1/37
Domestic Patent References:
| WO2001094416A2 | 2001-12-13 | |||
| WO2001083782A2 | 2001-11-08 |
Other References:
PERRY A C F ET AL: "ANALYSIS OF TRANSCRIPTS ENCODING NOVEL MEMBERS OF THE MAMMALIAN METALLOPROTEASE-LIKE, DISINTEGRIN-LIKE, CYSTEINE-RICH (MDC) PROTEINFAMILY AND THEIR EXPRESSION IN REPRODUCTIVE AND NON-REPRODUCTIVE MONKEY TISSUES", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 312, no. PART 1, 15 November 1995 (1995-11-15), pages 239 - 244, XP002069782, ISSN: 0264-6021
DATABASE MEDLINE [online] June 2000 (2000-06-01), ZHOU Q ET AL: "Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression.", XP002203869, Database accession no. NLM10966001
NATH DEEPA ET AL: "Meltrin gamma (ADAM-9) mediates cellular adhesion through alpha6beta1 integrin, leading to a marked induction of fibroblast cell motility.", JOURNAL OF CELL SCIENCE, vol. 113, no. 12, June 2000 (2000-06-01), pages 2319 - 2328, XP002203866, ISSN: 0021-9533
KUNTZ I D ET AL: "STRUCTURE-BASED MOLECULAR DESIGN", ACCOUNTS OF CHEMICAL RESEARCH, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 27, no. 5, May 1994 (1994-05-01), pages 117 - 123, XP000885741, ISSN: 0001-4842
DATABASE MEDLINE [online] June 2000 (2000-06-01), ZHOU Q ET AL: "Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression.", XP002203869, Database accession no. NLM10966001
NATH DEEPA ET AL: "Meltrin gamma (ADAM-9) mediates cellular adhesion through alpha6beta1 integrin, leading to a marked induction of fibroblast cell motility.", JOURNAL OF CELL SCIENCE, vol. 113, no. 12, June 2000 (2000-06-01), pages 2319 - 2328, XP002203866, ISSN: 0021-9533
KUNTZ I D ET AL: "STRUCTURE-BASED MOLECULAR DESIGN", ACCOUNTS OF CHEMICAL RESEARCH, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 27, no. 5, May 1994 (1994-05-01), pages 117 - 123, XP000885741, ISSN: 0001-4842
Download PDF:
Previous Patent: A HUMAN DISINTEGRIN PROTEIN
Next Patent: EXPRESSION VECTOR CODING P972 GENE FOR CANCER THERAPY AND ADENOVIRUS PRODUCING THE SAME
Next Patent: EXPRESSION VECTOR CODING P972 GENE FOR CANCER THERAPY AND ADENOVIRUS PRODUCING THE SAME