Title:
METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST
Document Type and Number:
WIPO Patent Application WO1998017268
Kind Code:
A3
Abstract:
The analgesic effectiveness of an tramadol is significantly enhanced by administering tramadol with the administration of an analgesia-enhancer which is a nontoxic NMDA receptor blocker and/or a nontoxic substance that blocks at least one major intracellular consequence of NMDA receptor activation.
Inventors:
CARUSO FRANK S
Application Number:
PCT/US1997/019075
Publication Date:
June 25, 1998
Filing Date:
October 21, 1997
Export Citation:
Assignee:
ALGOS PHARM CORP (US)
International Classes:
A61K31/135; A61K31/485; A61P29/00; A61K45/00; (IPC1-7): A61K31/165; A61K31/485; A61K31/135
Domestic Patent References:
| WO1996006822A1 | 1996-03-07 | |||
| WO1993017673A1 | 1993-09-16 |
Foreign References:
| EP0615749A2 | 1994-09-21 | |||
| US5516803A | 1996-05-14 | |||
| US5336691A | 1994-08-09 |
Other References:
PRICE ET AL: "Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats", PAIN, vol. 68, no. 1, 1996, pages 119 - 127, XP002061724
LEHMANN: "Tramadol for the management of acute pain", DRUGS, vol. 47, no. S1, 1994, pages 19 - 32, XP002061725
SEFRIN: "Therapie des Akuten Schmerzes im rahmen der Notfallmedizin", NOTFALL MEDIZIN, vol. 23, no. 4, 1997, pages 148 - 156, XP002061726
LIPMAN: "Analgesic drugs for neuropathic and sympathetically maintained pain", CLINICS IN GERIATRIC MEDICINE - PAIN MANAGEMENT, vol. 12, no. 3, August 1996 (1996-08-01), pages 501 - 515, XP002061727
BESSON: "LA COMPLEXITÉ DES ASPECTS PHYSIOPHARMACOLOGIQUES DE LA DOULEUR", DRUGS, vol. 53, no. s2, - 1997, pages 1 - 9, XP002061728
LEHMANN: "Tramadol for the management of acute pain", DRUGS, vol. 47, no. S1, 1994, pages 19 - 32, XP002061725
SEFRIN: "Therapie des Akuten Schmerzes im rahmen der Notfallmedizin", NOTFALL MEDIZIN, vol. 23, no. 4, 1997, pages 148 - 156, XP002061726
LIPMAN: "Analgesic drugs for neuropathic and sympathetically maintained pain", CLINICS IN GERIATRIC MEDICINE - PAIN MANAGEMENT, vol. 12, no. 3, August 1996 (1996-08-01), pages 501 - 515, XP002061727
BESSON: "LA COMPLEXITÉ DES ASPECTS PHYSIOPHARMACOLOGIQUES DE LA DOULEUR", DRUGS, vol. 53, no. s2, - 1997, pages 1 - 9, XP002061728
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