Title:
METHOD AND APPARATUS FOR IMPROVED DETERMINATION OF SPATIAL NON-AGGLOMERATED MAGNETIC PARTICLE DISTRIBUTION IN AN AREA OF EXAMINATION
Document Type and Number:
WIPO Patent Application WO2004091398
Kind Code:
A3
Abstract:
The invention relates to a method to prevent or reduce agglomeration of magnetic particles, wherein the magnetic particles are exposed to a varying magnetic field, more in particular, there is provided a method to determine the spatial distribution of magnetic particles in an examination area of an object of examination with the following steps: a) Generation of an imaging magnetic field with a first sub-area with lower 15 magnetic field strength and a second sub-area with a higher magnetic field strength, b) Change of the spatial location of both sub-areas in the area of examination, c) Acquisition of signals that depend on the magnetization in the area of examination influenced by this change, and d) Evaluation of said signals to obtain information about the spatial distribution of the signals in the area of examination, wherein the magnetic particles before or during the determining of the spatial distribution are exposed to a varying magnetic field at least some of the time, such as to reduce or prevent agglomeration of magnetic particles. The invention further relates to an apparatus to determine the spatial distribution of magnetic particles. The invention further relates to magnetic particle compositions having improved imaging properties in the method according to the invention.
Inventors:
GLEICH BERNHARD (DE)
Application Number:
PCT/IB2004/050450
Publication Date:
March 17, 2005
Filing Date:
April 15, 2004
Export Citation:
Assignee:
PHILIPS INTELLECTUAL PROPERTY (DE)
KONINKL PHILIPS ELECTRONICS NV (NL)
GLEICH BERNHARD (DE)
KONINKL PHILIPS ELECTRONICS NV (NL)
GLEICH BERNHARD (DE)
International Classes:
A61B5/05; A61B5/06; (IPC1-7): A61B5/06; A61K49/18
Domestic Patent References:
| WO1991002811A1 | 1991-03-07 |
Foreign References:
| US5370901A | 1994-12-06 | |||
| US4827945A | 1989-05-09 | |||
| US4849210A | 1989-07-18 |
Other References:
KAISER R ET AL: "Magnetic properties of stable dispersions of subdomain magnetite particles", JOURNAL OF APPLIED PHYSICS USA, vol. 41, no. 3, 1970, pages 1064 - 1072, XP002295575, ISSN: 0021-8979
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