Title:
METHOD AND CELLS FOR IDENTIFYING RIG-I PATHWAY REGULATORS
Document Type and Number:
WIPO Patent Application WO/2012/154271
Kind Code:
A3
Abstract:
Disclosed herein are methods for identifying compounds for the treatment of viral infection, including RNA viral infection and uses of the compounds as pharmaceutical compositions. The identified compounds modulate the RIG-I pathway in vertebrate cells.
Inventors:
IADONATO SHAWN P (US)
BEDARD KRISTIN (US)
BEDARD KRISTIN (US)
Application Number:
PCT/US2012/026387
Publication Date:
February 21, 2013
Filing Date:
February 23, 2012
Export Citation:
Assignee:
KINETA INC (US)
IADONATO SHAWN P (US)
BEDARD KRISTIN (US)
IADONATO SHAWN P (US)
BEDARD KRISTIN (US)
International Classes:
A61K31/5415; A61K31/538; A61K48/00; A61P31/12; A61P31/16
Domestic Patent References:
| WO2012003030A2 | 2012-01-05 |
Other References:
PICHLMAIR, A. ET AL.: "RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates", SCIENCE, vol. 314, no. 5801, 10 November 2006 (2006-11-10), pages 997 - 1001, XP009081711
RANDALL, R. E. ET AL.: "Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures", J. GEN. VIROL., vol. 89, no. 1, January 2008 (2008-01-01), pages 1 - 47, XP055121869
KATO, H. ET AL.: "Cell type-specific involvement of RIG-I in antiviral response", IMMUNITY, vol. 23, no. 1, July 2005 (2005-07-01), pages 19 - 28, XP003017393
RANDALL, R. E. ET AL.: "Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures", J. GEN. VIROL., vol. 89, no. 1, January 2008 (2008-01-01), pages 1 - 47, XP055121869
KATO, H. ET AL.: "Cell type-specific involvement of RIG-I in antiviral response", IMMUNITY, vol. 23, no. 1, July 2005 (2005-07-01), pages 19 - 28, XP003017393
Attorney, Agent or Firm:
WINGER, Rachal, C. et al. (925 Fourth Avenue Suite 290, Seattle WA, US)
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