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Title:
METHOD AND COMPOSITION FOR PREVENTING MULTIPLE ORGAN DYSFUNCTION SYNDROME
Document Type and Number:
WIPO Patent Application WO2005027660
Kind Code:
A3
Abstract:
One aspect of the present invention relates to a method of preventing multiple organ dysfunction syndrome in a mammal suffering from trauma, said method comprising enterally administering to said mammal, within 24 hours of the occurrence of the trauma, (i) digestible water soluble carbohydrates and (ii) a liver guanosine-5'-triphosphate (GTP) increasing component and/or peptides with Angiotensin Converting Enzyme (ACE) inhibiting activity. Another aspect of the invention relates to an aqueous liquid composition containing: - 20-200 g/l digestible dissolved carbohydrates; - 5-5000 mg/l guanosine equivalents in combination with 1-100 g/l ribose equivalents and/or 2-2000 mg/I flavonoids; or 0.01 to 10 mM of peptides with ACE inhibiting activity; and - 45 to 97.95 wt.% water.

Inventors:
VAN NORREN KLASKE (NL)
VAN HOORN EDUARD CHRISTIAN (NL)
HAGEMAN ROBERT JOHAN JOSEPH (NL)
BOURITIUS HOUKJE (NL)
VRIESEMA ADRIANUS JOHANNES MAR (NL)
VAN LIMPT CORNELUS JOHANNES PE (NL)
LANSINK MIRIAN (NL)
VAN MEETEREN MARIEKE ELISE (NL)
Application Number:
PCT/NL2004/000650
Publication Date:
November 03, 2005
Filing Date:
September 20, 2004
Export Citation:
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Assignee:
NUTRICIA NV (NL)
VAN NORREN KLASKE (NL)
VAN HOORN EDUARD CHRISTIAN (NL)
HAGEMAN ROBERT JOHAN JOSEPH (NL)
BOURITIUS HOUKJE (NL)
VRIESEMA ADRIANUS JOHANNES MAR (NL)
VAN LIMPT CORNELUS JOHANNES PE (NL)
LANSINK MIRIAN (NL)
VAN MEETEREN MARIEKE ELISE (NL)
International Classes:
A23L1/09; A23L1/30; A23L1/305; A23L33/00; (IPC1-7): A23L1/29; A23L1/09; A23L1/305; A23L1/30
Domestic Patent References:
WO2003074129A12003-09-12
Foreign References:
US5438043A1995-08-01
EP0875155A11998-11-04
EP0302807A21989-02-08
US5700590A1997-12-23
US20020183263A12002-12-05
US5602109A1997-02-11
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