Title:
METHOD AND COMPOSITIONS FOR TREATING RESPIRATORY PATHOLOGIES
Document Type and Number:
WIPO Patent Application WO2003053422
Kind Code:
A3
Abstract:
The invention concerns compositions and methods for treating respiratory pathologies. The invention also concerns compositions and methods for regulating pulmonary epithelium paracellular permeability. The inventive compositions and methods are based in particular on the use of agents or conditions modulating the cytoskeleton tension, more particularly compounds inhibiting contraction of the light chain of pulmonary epithelial cell myosin, in particular enterocytes. The invention is useful for preventive or curative treatment of various pathologies, such as asthma, allergies, chronic obstructive lung diseases and the like in mammals, in particular humans.
Inventors:
BUENO LIONEL (FR)
Application Number:
PCT/FR2002/004506
Publication Date:
April 15, 2004
Filing Date:
December 20, 2002
Export Citation:
Assignee:
RYTEK (FR)
BUENO LIONEL (FR)
BUENO LIONEL (FR)
International Classes:
A61K31/00; A61K31/185; A61P11/00; A61P11/06; (IPC1-7): A61K31/00; A61K31/185; A61K31/366; A61K31/551; A61P11/00; A61P11/06
Domestic Patent References:
| WO2000003746A2 | 2000-01-27 |
Foreign References:
| EP0638564A1 | 1995-02-15 | |||
| US5883114A | 1999-03-16 |
Other References:
MARUOKA ET AL.: "Involvement of Rho and Myosin Light Chain Kinase in neutrophil elastase-induced morphological changes in airway epithelial cells", AM. J. RESPIR. CRITICAL CARE MED., vol. 159, no. 3suppl., 1999, pages a187, XP008022808
GARCIA J G ET AL: "Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60(src).", THE AMERICAN JOURNAL OF PHYSIOLOGY. UNITED STATES JUN 1999, vol. 276, no. 6 Pt 1, June 1999 (1999-06-01), pages L989 - L998, XP002256896, ISSN: 0002-9513
PARKER J C: "Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD.: 1985) UNITED STATES DEC 2000, vol. 89, no. 6, December 2000 (2000-12-01), pages 2241 - 2248, XP001165791, ISSN: 8750-7587
GARCIA J G ET AL: "Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD.: 1985) UNITED STATES MAY 1998, vol. 84, no. 5, May 1998 (1998-05-01), pages 1817 - 1821, XP001165792, ISSN: 8750-7587
WYATT T A ET AL: "Stimulation of protein kinase C activity by tumor necrosis factor-[alpha] in bovine bronchial epithelial cells", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 1997 UNITED STATES, vol. 273, no. 5 17-5, 1997, pages L1007 - L1012, XP001165793, ISSN: 1040-0605
VOLBERG T ET AL: "Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system.", CELL MOTILITY AND THE CYTOSKELETON. UNITED STATES 1994, vol. 29, no. 4, 1994, pages 321 - 338, XP008022805, ISSN: 0886-1544
KOBAYASHI K ET AL: "MECHANISM OF HYDROGEN PEROXIDE-INDUCED INHIBITION OF SHEEP AIRWAY CILIA", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 6, no. 6, 1992, pages 667 - 673, XP008022800, ISSN: 1044-1549
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1994, LIU XUELIANG ET AL: "Myosin Light Chain Phosphatase Activity in Ragweed Pollen-Sensitized Canine Tracheal Smooth Muscle", XP002256897, Database accession no. PREV199598078691
LEFF A R: "Pharmacologic management of asthma", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 1998 UNITED STATES, vol. 101, no. 2 II, 1998, pages S397 - S399, XP008022810, ISSN: 0091-6749
AHDIEH M ET AL: "LUNG EPITHELIAL BARRIER FUNCTION AND WOUND HEALING ARE DECREASED BY IL-4 AND IL-13 ENHANCED BY IFN-GAMMA", AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 281, no. 6, December 2001 (2001-12-01), pages C2029 - C2038, XP008007756, ISSN: 0363-6143
GODFREY R W A: "HUMAN AIRWAY EPITHELIAL TIGHT JUNCTIONS", MICROSCOPY RESEARCH AND TECHNIQUE, WILEY-LISS, CHICHESTER, GB, vol. 38, no. 5, 1 September 1997 (1997-09-01), pages 488 - 499, XP008007862, ISSN: 1059-910X
KOBAYASHI N ET AL: "IMMUNOHISTOCHEMICAL STUDY OF E-CADHERIN AND ZO-1 IN ALLERGIC NASAL EPITHELIUM OF THE GUINEA PIG", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, XX, XX, vol. 116, no. 3, July 1998 (1998-07-01), pages 196 - 205, XP008007809, ISSN: 1018-2438
DATABASE MEDLINE [online] November 1990 (1990-11-01), OHASHI Y ET AL: "[Relationship between bronchial reactivity to inhaled acetylcholine, eosinophil infiltration and a widening of the intercellular space in patients with asthma]", XP002216574, Database accession no. NLM2288500
CITI S ET AL: "CYTOSKELETAL INVOLVEMENT IN THE MODULATION OF CELL-CELL JUNCTIONS BY THE PROTEIN KINASE INHIBITOR H-7", JOURNAL OF CELL SCIENCE, ESSEX, GB, vol. 107, no. 3, 1994, pages 683 - 692, XP002040798
CITI S: "PROTEIN KINASE INHIBITORS PREVENT JUNCTIONS DISSOCIATION INDUCED BY LOW EXTRACELLULAR CALCIUM IN MDCK EPITHELIAL CELLS", JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, NEW YORK, US, US, vol. 117, no. 1, April 1992 (1992-04-01), pages 169 - 178, XP008007882, ISSN: 0021-9525
PETRACHE I ET AL: "DIFFERENTIAL EFFECT OF MLC KINASE IN TNF-ALPHA-INDUCED ENDOTHELIAL CELL APOPTOSIS AND BARRIER DYSFUNCTION", AMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, XX, XX, vol. 280, no. 6, June 2001 (2001-06-01), pages L1168 - L1178, XP001128712, ISSN: 1040-0605
See also references of EP 1455767A2
GARCIA J G ET AL: "Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60(src).", THE AMERICAN JOURNAL OF PHYSIOLOGY. UNITED STATES JUN 1999, vol. 276, no. 6 Pt 1, June 1999 (1999-06-01), pages L989 - L998, XP002256896, ISSN: 0002-9513
PARKER J C: "Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD.: 1985) UNITED STATES DEC 2000, vol. 89, no. 6, December 2000 (2000-12-01), pages 2241 - 2248, XP001165791, ISSN: 8750-7587
GARCIA J G ET AL: "Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD.: 1985) UNITED STATES MAY 1998, vol. 84, no. 5, May 1998 (1998-05-01), pages 1817 - 1821, XP001165792, ISSN: 8750-7587
WYATT T A ET AL: "Stimulation of protein kinase C activity by tumor necrosis factor-[alpha] in bovine bronchial epithelial cells", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 1997 UNITED STATES, vol. 273, no. 5 17-5, 1997, pages L1007 - L1012, XP001165793, ISSN: 1040-0605
VOLBERG T ET AL: "Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system.", CELL MOTILITY AND THE CYTOSKELETON. UNITED STATES 1994, vol. 29, no. 4, 1994, pages 321 - 338, XP008022805, ISSN: 0886-1544
KOBAYASHI K ET AL: "MECHANISM OF HYDROGEN PEROXIDE-INDUCED INHIBITION OF SHEEP AIRWAY CILIA", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 6, no. 6, 1992, pages 667 - 673, XP008022800, ISSN: 1044-1549
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1994, LIU XUELIANG ET AL: "Myosin Light Chain Phosphatase Activity in Ragweed Pollen-Sensitized Canine Tracheal Smooth Muscle", XP002256897, Database accession no. PREV199598078691
LEFF A R: "Pharmacologic management of asthma", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 1998 UNITED STATES, vol. 101, no. 2 II, 1998, pages S397 - S399, XP008022810, ISSN: 0091-6749
AHDIEH M ET AL: "LUNG EPITHELIAL BARRIER FUNCTION AND WOUND HEALING ARE DECREASED BY IL-4 AND IL-13 ENHANCED BY IFN-GAMMA", AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 281, no. 6, December 2001 (2001-12-01), pages C2029 - C2038, XP008007756, ISSN: 0363-6143
GODFREY R W A: "HUMAN AIRWAY EPITHELIAL TIGHT JUNCTIONS", MICROSCOPY RESEARCH AND TECHNIQUE, WILEY-LISS, CHICHESTER, GB, vol. 38, no. 5, 1 September 1997 (1997-09-01), pages 488 - 499, XP008007862, ISSN: 1059-910X
KOBAYASHI N ET AL: "IMMUNOHISTOCHEMICAL STUDY OF E-CADHERIN AND ZO-1 IN ALLERGIC NASAL EPITHELIUM OF THE GUINEA PIG", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, XX, XX, vol. 116, no. 3, July 1998 (1998-07-01), pages 196 - 205, XP008007809, ISSN: 1018-2438
DATABASE MEDLINE [online] November 1990 (1990-11-01), OHASHI Y ET AL: "[Relationship between bronchial reactivity to inhaled acetylcholine, eosinophil infiltration and a widening of the intercellular space in patients with asthma]", XP002216574, Database accession no. NLM2288500
CITI S ET AL: "CYTOSKELETAL INVOLVEMENT IN THE MODULATION OF CELL-CELL JUNCTIONS BY THE PROTEIN KINASE INHIBITOR H-7", JOURNAL OF CELL SCIENCE, ESSEX, GB, vol. 107, no. 3, 1994, pages 683 - 692, XP002040798
CITI S: "PROTEIN KINASE INHIBITORS PREVENT JUNCTIONS DISSOCIATION INDUCED BY LOW EXTRACELLULAR CALCIUM IN MDCK EPITHELIAL CELLS", JOURNAL OF CELL BIOLOGY, ROCKEFELLER UNIVERSITY PRESS, NEW YORK, US, US, vol. 117, no. 1, April 1992 (1992-04-01), pages 169 - 178, XP008007882, ISSN: 0021-9525
PETRACHE I ET AL: "DIFFERENTIAL EFFECT OF MLC KINASE IN TNF-ALPHA-INDUCED ENDOTHELIAL CELL APOPTOSIS AND BARRIER DYSFUNCTION", AMERICAN JOURNAL OF PHYSIOLOGY. LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, XX, XX, vol. 280, no. 6, June 2001 (2001-06-01), pages L1168 - L1178, XP001128712, ISSN: 1040-0605
See also references of EP 1455767A2
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