Title:
METHOD FOR DETECTING COLORECTAL TUMOR
Document Type and Number:
WIPO Patent Application WO/2021/246533
Kind Code:
A1
Abstract:
To identify bacteria associated with multiple polyps or an intra-mucosa cancer and establish a novel colorectal tumor detection means based on these bacteria, a method for detecting a colorectal tumor is provided, the method being characterized by including the following steps (1) to (3): (1) a step for measuring an amount of microorganisms such as Actinomyces odontolyticus in the feces of a subject; (2) a step for comparing the value measured in step (1) with a corresponding value in the feces of a normal person; and (3) a step for determining, on the basis of the result of the comparison in step (2), that the subject has colorectal tumor when the value measured in step (1) is higher or lower than the corresponding value in the feces of the normal person.
Inventors:
YAMADA TAKUJI (JP)
FUKUDA SHINJI (JP)
YACHIDA SHINICHI (JP)
FUKUDA SHINJI (JP)
YACHIDA SHINICHI (JP)
Application Number:
PCT/JP2021/021647
Publication Date:
December 09, 2021
Filing Date:
June 07, 2021
Export Citation:
Assignee:
TOKYO INST TECH (JP)
UNIV KEIO (JP)
NAT CANCER CT (JP)
UNIV KEIO (JP)
NAT CANCER CT (JP)
International Classes:
C12Q1/06; C12N15/00; C12Q1/6809
Other References:
YACHIDA, S. ET AL.: "Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer", NATURE MEDICINE, vol. 25, 2019, pages 968 - 976, XP036901080, DOI: 10.1038/s41591-019-0458-7
MIZUTANI SAYAKA, YAMADA TAKUJI, YACHIDA SHINICHI: "Significance of the gut microbiome in multistep colorectal carcinogenesis", CANCER SCIENCE, vol. 111, no. 3, 7 January 2020 (2020-01-07), pages 766 - 773, XP055879621
MIZUTANI SAYAKA, YAMADA TAKUJI, YACHIDA SHINICHI: "Significance of the gut microbiome in multistep colorectal carcinogenesis", CANCER SCIENCE, vol. 111, no. 3, 7 January 2020 (2020-01-07), pages 766 - 773, XP055879621
Attorney, Agent or Firm:
NOMURA, Kenichi et al. (JP)
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