Title:
METHOD OF DETECTING ENDOMETRIOSIS
Document Type and Number:
WIPO Patent Application WO2000059547
Kind Code:
A3
Abstract:
Kits for detecting and treating endometriosis are provided, which contain a targeting molecule comprising an eosinophil peroxidase-binding component. Methods of detecting and treating endometriosis using eosinophil peroxidase-specific targeting molecules are also provided. Targeting molecules comprise an eosinophil peroxidase-binding component and an accessory component; the accessory component comprising an agent conferring detectability or a therapeutic effect.
Inventors:
BLUMENTHAL ROSALYN D (US)
GOLDENBERG DAVID M (US)
SAMOSZUK MICHAEL (US)
GOLDENBERG DAVID M (US)
SAMOSZUK MICHAEL (US)
Application Number:
PCT/US2000/008581
Publication Date:
July 26, 2001
Filing Date:
March 31, 2000
Export Citation:
Assignee:
CT MOLECULAR MED & IMMUNOLOGY (US)
BLUMENTHAL ROSALYN D (US)
GOLDENBERG DAVID M (US)
SAMOSZUK MICHAEL (US)
BLUMENTHAL ROSALYN D (US)
GOLDENBERG DAVID M (US)
SAMOSZUK MICHAEL (US)
International Classes:
A61B5/055; A61K45/00; A61K47/48; G01R33/28; A61K49/00; A61K51/10; A61P15/00; G01N33/50; G01N33/573; G01N33/68; (IPC1-7): A61K47/48; A61K51/10; A61K49/00
Foreign References:
| US5631247A | 1997-05-20 | |||
| US5856341A | 1999-01-05 |
Other References:
SAMOSZUK M ET AL: "New marker for blood vessels in human ovarian and endometrial cancers.", CLINICAL CANCER RESEARCH, NOV 1996, VOL. 2, NO. 11, PAGE(S) 1867-71, XP002156536
SAMOSZUK MK ET AL: "Radioimmunodetection of degranulated human eosinophils in mice: a potential model for imaging Hodgkin's disease and other pathologic conditions.", JOURNAL OF NUCLEAR MEDICINE, JAN 1991, VOL. 32, NO. 1, PAGE(S) 89-94, XP002156537
KEEPING HS ET AL: "Monoclonal antibody to rat uterine peroxidase and its use in identification of the peroxidase as being of eosinophil origin.", BIOCHIMICA ET BIOPHYSICA ACTA, DEC 20 1984, VOL. 802, NO. 3, PAGE(S) 399-406, XP000971511
SKUBITZ KM ET AL: "Preparation and characterization of monoclonal antibodies to human neutrophil cathepsin G, lactoferrin, eosinophil peroxidase, and eosinophil major basic protein.", JOURNAL OF LEUKOCYTE BIOLOGY, AUG 1989, VOL. 46, NO. 2, PAGE(S) 109-18, XP000971423
PEREZ MC ET AL: "Role of eosinophils in uterine responses to estrogen.", BIOLOGY OF REPRODUCTION, JAN 1996, VOL. 54, NO. 1, PAGE(S) 249-54, XP000971428
BRYANT H U ET AL: "PHARMACOLOGIC PROFILE OF ESTROGEN-INDUCED UTERINE EOSINOPHILIA IN THE OVARIECTOMIZED (OVX) RAT", PHARMACOLOGIST,BETHESDA, MD,US, vol. 34, no. 3, 18 August 1992 (1992-08-18), & ASPET 1992, Orlando, Florida, US, 14-18 August 1992, pages 194, abstract nr. 318, XP000971363, ISSN: 0031-7004
PRESS M F ET AL: "DISTRIBUTION OF PEROXIDASE AND GRANULOCYTES IN THE HUMAN UTERUS", LABORATORY INVESTIGATION, vol. 54, no. 2, 1986, pages 188 - 203, XP000971137, ISSN: 0023-6837
MENA M A ET AL: "INHIBITION OF NON-GENOMIC RESPONSES TO ESTROGEN IN THE RAT UTERUS BY TESTOSTERONE PROPIONATE", JOURNAL OF REPRODUCTION AND FERTILITY, vol. 74, no. 1, 1985, pages 1 - 8, XP000971132, ISSN: 0022-4251
MCMASTER M T ET AL: "ACTIVATION AND DISTRIBUTION OF INFLAMMATORY CELLS IN THE MOUSE UTERUS DURING THE PREIMPLANTATION PERIOD", JOURNAL OF IMMUNOLOGY, vol. 148, no. 6, 1992, pages 1699 - 1705, XP002156538, ISSN: 0022-1767
KING W J ET AL: "LOCALIZATION OF UTERINE PEROXIDASE ACTIVITY IN ESTROGEN TREATED RATS", BIOLOGY OF REPRODUCTION, vol. 25, no. 4, 1981, pages 859 - 870, XP000971130, ISSN: 0006-3363
SAMOSZUK MK ET AL: "Radioimmunodetection of degranulated human eosinophils in mice: a potential model for imaging Hodgkin's disease and other pathologic conditions.", JOURNAL OF NUCLEAR MEDICINE, JAN 1991, VOL. 32, NO. 1, PAGE(S) 89-94, XP002156537
KEEPING HS ET AL: "Monoclonal antibody to rat uterine peroxidase and its use in identification of the peroxidase as being of eosinophil origin.", BIOCHIMICA ET BIOPHYSICA ACTA, DEC 20 1984, VOL. 802, NO. 3, PAGE(S) 399-406, XP000971511
SKUBITZ KM ET AL: "Preparation and characterization of monoclonal antibodies to human neutrophil cathepsin G, lactoferrin, eosinophil peroxidase, and eosinophil major basic protein.", JOURNAL OF LEUKOCYTE BIOLOGY, AUG 1989, VOL. 46, NO. 2, PAGE(S) 109-18, XP000971423
PEREZ MC ET AL: "Role of eosinophils in uterine responses to estrogen.", BIOLOGY OF REPRODUCTION, JAN 1996, VOL. 54, NO. 1, PAGE(S) 249-54, XP000971428
BRYANT H U ET AL: "PHARMACOLOGIC PROFILE OF ESTROGEN-INDUCED UTERINE EOSINOPHILIA IN THE OVARIECTOMIZED (OVX) RAT", PHARMACOLOGIST,BETHESDA, MD,US, vol. 34, no. 3, 18 August 1992 (1992-08-18), & ASPET 1992, Orlando, Florida, US, 14-18 August 1992, pages 194, abstract nr. 318, XP000971363, ISSN: 0031-7004
PRESS M F ET AL: "DISTRIBUTION OF PEROXIDASE AND GRANULOCYTES IN THE HUMAN UTERUS", LABORATORY INVESTIGATION, vol. 54, no. 2, 1986, pages 188 - 203, XP000971137, ISSN: 0023-6837
MENA M A ET AL: "INHIBITION OF NON-GENOMIC RESPONSES TO ESTROGEN IN THE RAT UTERUS BY TESTOSTERONE PROPIONATE", JOURNAL OF REPRODUCTION AND FERTILITY, vol. 74, no. 1, 1985, pages 1 - 8, XP000971132, ISSN: 0022-4251
MCMASTER M T ET AL: "ACTIVATION AND DISTRIBUTION OF INFLAMMATORY CELLS IN THE MOUSE UTERUS DURING THE PREIMPLANTATION PERIOD", JOURNAL OF IMMUNOLOGY, vol. 148, no. 6, 1992, pages 1699 - 1705, XP002156538, ISSN: 0022-1767
KING W J ET AL: "LOCALIZATION OF UTERINE PEROXIDASE ACTIVITY IN ESTROGEN TREATED RATS", BIOLOGY OF REPRODUCTION, vol. 25, no. 4, 1981, pages 859 - 870, XP000971130, ISSN: 0006-3363
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