Title:
METHOD FOR DETECTING PARKINSON DISEASE
Document Type and Number:
WIPO Patent Application WO/2021/230379
Kind Code:
A1
Abstract:
Provided are a marker gene for detecting Parkinson disease and a method for detecting Parkinson disease using said marker gene. Said method for detecting Parkinson disease in a subject comprises a step for measuring the expression level of at least one gene selected in a group of four genes consisting of SNORA16A, SNORA24, SNORA50 and REXO1L2P or for measuring the expression level of an expression product of said gene, in a biological sample collected from said subject.
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Inventors:
UEHARA YUYA (JP)
INOUE TAKAYOSHI (JP)
HATTORI NOBUTAKA (JP)
SAIKI SHINJI (JP)
UENO SHIN-ICHI (JP)
TAKESHIGE HARUKA (JP)
INOUE TAKAYOSHI (JP)
HATTORI NOBUTAKA (JP)
SAIKI SHINJI (JP)
UENO SHIN-ICHI (JP)
TAKESHIGE HARUKA (JP)
Application Number:
PCT/JP2021/018511
Publication Date:
November 18, 2021
Filing Date:
May 14, 2021
Export Citation:
Assignee:
KAO CORP (JP)
JUNTENDO EDUCATIONAL FOUND (JP)
JUNTENDO EDUCATIONAL FOUND (JP)
International Classes:
C12Q1/6832; G01N33/50
Domestic Patent References:
| WO2020025967A1 | 2020-02-06 | |||
| WO2018008319A1 | 2018-01-11 | |||
| WO2018008319A1 | 2018-01-11 |
Foreign References:
| JP2019506183A | 2019-03-07 | |||
| JP2016075644A | 2016-05-12 |
Other References:
YASIN NASRA, VEENMAN LEO, DIMITROVA-SHUMKOVSKA JASMINA, GAVISH MOSHE: "The 18 kDa translocator protein, non-coding RNA, and homeostasis", NON-CODING RNA INVESTIGATION, vol. 1, pages 25 - 25, XP055872217, ISSN: 2522-6673, DOI: 10.21037/ncri.2017.12.02
TOKUDA TAKAHIRO: "Aiming to develop biochemical biomarkers for Parkinson's disease and related disorders", CLINICAL NEUROLOGY, 1 January 2012 (2012-01-01), pages 1332 - 1334, XP055872265, [retrieved on 20211213], DOI: 10.1371/journal.pone.0037214
OBA SHIGEYUKI: "Prediction and Estimation from Gene Expression Data Analysis: What We Want to and be Able to Conclude from Data", PROCEEDINGS OF THE INSTITUTE OF STATISTICAL MATHEMATICS, 1 January 2006 (2006-01-01), pages 405 - 423, XP055872271, Retrieved from the Internet [retrieved on 20211213]
RODRIGUEZ-LEYVA I ET AL., ANN CLIN TRANSL NEUROL., 2014
RAVN AH ET AL., CLIN COSMET INVESTIG DERMATOL., 2017
LOVE MI ET AL., GENOME BIOL., 2014
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
PNAS, vol. 100, 2003, pages 12271 - 12276
BIOL. REPROD., vol. 58, 1998, pages 302 - 311
GRIFFITHS, A.D.DUNCAN, A.R., CURRENT OPINION IN BIOTECHNOLOGY, vol. 9, no. 1, February 1998 (1998-02-01), pages 102 - 108
TOKUDA TAKAHIRO: "Aiming to develop biochemical biomarkers for Parkinson's disease and related disorders", CLINICAL NEUROLOGY, 1 January 2012 (2012-01-01), pages 1332 - 1334, XP055872265, [retrieved on 20211213], DOI: 10.1371/journal.pone.0037214
OBA SHIGEYUKI: "Prediction and Estimation from Gene Expression Data Analysis: What We Want to and be Able to Conclude from Data", PROCEEDINGS OF THE INSTITUTE OF STATISTICAL MATHEMATICS, 1 January 2006 (2006-01-01), pages 405 - 423, XP055872271, Retrieved from the Internet
RODRIGUEZ-LEYVA I ET AL., ANN CLIN TRANSL NEUROL., 2014
RAVN AH ET AL., CLIN COSMET INVESTIG DERMATOL., 2017
LOVE MI ET AL., GENOME BIOL., 2014
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
PNAS, vol. 100, 2003, pages 12271 - 12276
BIOL. REPROD., vol. 58, 1998, pages 302 - 311
GRIFFITHS, A.D.DUNCAN, A.R., CURRENT OPINION IN BIOTECHNOLOGY, vol. 9, no. 1, February 1998 (1998-02-01), pages 102 - 108
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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