Title:
METHOD FOR DETECTING PROGRANULIN
Document Type and Number:
WIPO Patent Application WO/2024/085222
Kind Code:
A1
Abstract:
Provided is a method for detecting progranulin, said method being characterized by using: an antibody that is bounded specifically to the P domain or the G domain of progranulin; and an antibody that is bounded specifically to the E domain of progranulin.
Inventors:
YAMAUCHI RYOSUKE (JP)
KOBAYASHI HIRONORI (JP)
KOBAYASHI HIRONORI (JP)
Application Number:
PCT/JP2023/037848
Publication Date:
April 25, 2024
Filing Date:
October 19, 2023
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
International Classes:
G01N33/53
Foreign References:
| JP2009538631A | 2009-11-12 | |||
| US20210284701A1 | 2021-09-16 | |||
| JP2014238343A | 2014-12-18 |
Other References:
SWETHA MOHAN: "Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration", MOLECULAR NEURODEGENERATION, BIOMED CENTRAL LTD, LO, vol. 16, no. 1, 3 August 2021 (2021-08-03), Lo , pages 51, XP093160439, ISSN: 1750-1326, DOI: 10.1186/s13024-021-00472-1
YANQING LI: "A Highly Sensitive Sandwich ELISA to Detect CSF Progranulin: A Potential Biomarker for CNS Disorders", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, LIPPINCOTT WILLIAMS AND WILKINS., NEW YORK, NY., vol. 78, no. 5, 1 May 2019 (2019-05-01), NEW YORK, NY. , pages 406 - 415, XP093160440, ISSN: 0022-3069, DOI: 10.1093/jnen/nlz022
YANQING LI: "Biological function analysis of monoclonal antibodies against human granulins in vitro using U251 cells as a model", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA., vol. 130, 1 February 2017 (2017-02-01), SAN DIEGO, CA. , pages 55 - 62, XP093160441, ISSN: 1046-5928, DOI: 10.1016/j.pep.2016.09.019
CHRISTOPHER J. HOLLER: "Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations", ENEURO, vol. 4, no. 4, 1 July 2017 (2017-07-01), pages ENEURO.0100 - 17.2017, XP093160442, ISSN: 2373-2822, DOI: 10.1523/ENEURO.0100-17.2017
LIHONG CHAI: "Domain-Specific Monoclonal Antibodies Produced Against Human PGRN", HYBRIDOMA, MARY ANN LIEBERT, INC. PUBLISHERS, US, vol. 30, no. 3, 1 June 2011 (2011-06-01), US , pages 271 - 278, XP093160444, ISSN: 1554-0014, DOI: 10.1089/hyb.2010.0112
CHING KATHRYN H., BERG KIMBERLEY, REYNOLDS KEVIN, PEDERSEN DARLENE, MACIAS ALBA, ABDICHE YASMINA N., HARRIMAN WILLIAM D., LEIGHTON: "Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics", MABS, LANDES BIOSCIENCE, US, vol. 13, no. 1, 25 January 2021 (2021-01-25), US , XP055878213, ISSN: 1942-0862, DOI: 10.1080/19420862.2020.1862451
YANQING LI: "A Highly Sensitive Sandwich ELISA to Detect CSF Progranulin: A Potential Biomarker for CNS Disorders", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, LIPPINCOTT WILLIAMS AND WILKINS., NEW YORK, NY., vol. 78, no. 5, 1 May 2019 (2019-05-01), NEW YORK, NY. , pages 406 - 415, XP093160440, ISSN: 0022-3069, DOI: 10.1093/jnen/nlz022
YANQING LI: "Biological function analysis of monoclonal antibodies against human granulins in vitro using U251 cells as a model", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA., vol. 130, 1 February 2017 (2017-02-01), SAN DIEGO, CA. , pages 55 - 62, XP093160441, ISSN: 1046-5928, DOI: 10.1016/j.pep.2016.09.019
CHRISTOPHER J. HOLLER: "Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations", ENEURO, vol. 4, no. 4, 1 July 2017 (2017-07-01), pages ENEURO.0100 - 17.2017, XP093160442, ISSN: 2373-2822, DOI: 10.1523/ENEURO.0100-17.2017
LIHONG CHAI: "Domain-Specific Monoclonal Antibodies Produced Against Human PGRN", HYBRIDOMA, MARY ANN LIEBERT, INC. PUBLISHERS, US, vol. 30, no. 3, 1 June 2011 (2011-06-01), US , pages 271 - 278, XP093160444, ISSN: 1554-0014, DOI: 10.1089/hyb.2010.0112
CHING KATHRYN H., BERG KIMBERLEY, REYNOLDS KEVIN, PEDERSEN DARLENE, MACIAS ALBA, ABDICHE YASMINA N., HARRIMAN WILLIAM D., LEIGHTON: "Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics", MABS, LANDES BIOSCIENCE, US, vol. 13, no. 1, 25 January 2021 (2021-01-25), US , XP055878213, ISSN: 1942-0862, DOI: 10.1080/19420862.2020.1862451
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
Download PDF: