METHOD AND DEVICE FOR DETERMINING PROPORTION OF FREE NUCLEOTIDE FROM PREDETERMINED SOURCE IN BIOLOGICAL SAMPLE

Title:

METHOD AND DEVICE FOR DETERMINING PROPORTION OF FREE NUCLEOTIDE FROM PREDETERMINED SOURCE IN BIOLOGICAL SAMPLE

Document Type and Number:

WIPO Patent Application WO/2018/137496

Kind Code:

A1

Abstract:

Disclosed are a method and device for determining the proportion of a free nucleotide from a predetermined source in a biological sample. The method comprises: (1) performing nucleic acid sequencing on a biological sample comprising a free nucleotide to obtain a sequencing result consisting of multiple pieces of sequencing data; (2) comparing the sequencing result with a reference sequence to determine the number of pieces of sequencing data falling within a predetermined window in the sequencing result; and (3) determining the proportion of the free nucleotide from a predetermined source in the biological sample on the basis of the number of pieces of sequencing data falling within the predetermined window.

Inventors:

YUAN YUYING (CN)
CHAI XIANGHUA (CN)
WANG SHUYUAN (CN)
CHEN LINA (CN)
ZHOU LIJUN (CN)
LIU QIANG (CN)
ZHANG HONGYUN (CN)
WANG WEI (CN)
LIU NA (CN)
YIN YE (CN)

Application Number:

PCT/CN2018/072045

Publication Date:

August 02, 2018

Filing Date:

January 10, 2018

Export Citation:

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Assignee:

BGI GENOMICS CO LTD (CN)

International Classes:

C12Q1/68; C12M1/00

Domestic Patent References:

WO2014043763A1

2014-03-27

Foreign References:

CN105296606A	2016-02-03
CN105331606A	2016-02-17

Other References: