Title:
METHOD FOR DIAGNOSING INFLAMMATORY DISEASES AND INFECTIONS BY THE DETERMINATION OF LASP-1/LAP-1
Document Type and Number:
WIPO Patent Application WO2003089934
Kind Code:
A3
Abstract:
The invention relates to a method for the early detection and identification, for a prognosis on the course, assessment of the severity and assessment during the course of therapy of inflammatory diseases and infections, in particular systemic infections similar to septicaemia and Alzheimer's disease. According to said method, the presence and/or quantity of the protein LASP-1 (SEQ ID NO:1), or the protein LAP-1 (SEQ ID NO:16), or an immunoreactive fragment of one of said proteins is determined, preferably as immunoreactivity, in a free and/or protein-bound form in a biological liquid, or optionally a tissue sample of a patient and conclusions are drawn from the presence and/or quantity of the specific proteins with regard to the existence, the expected course, the severity or the success of a therapy of the inflammatory disease or the infection.
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Inventors:
BERGMANN ANDREAS (DE)
FISCHER-SCHULZ CHRISTINA (DE)
STRUCK JOACHIM (DE)
FISCHER-SCHULZ CHRISTINA (DE)
STRUCK JOACHIM (DE)
Application Number:
PCT/EP2003/003940
Publication Date:
April 01, 2004
Filing Date:
April 15, 2003
Export Citation:
Assignee:
BRAHMS AG (DE)
BERGMANN ANDREAS (DE)
FISCHER-SCHULZ CHRISTINA (DE)
STRUCK JOACHIM (DE)
BERGMANN ANDREAS (DE)
FISCHER-SCHULZ CHRISTINA (DE)
STRUCK JOACHIM (DE)
International Classes:
A61K38/17; A61K45/00; A61P9/00; A61P25/28; G01N33/53; A61P29/00; A61P31/00; C07K14/47; C07K16/18; G01N33/543; G01N33/566; G01N33/574; G01N33/68; (IPC1-7): G01N33/68; G01N33/574; C07K14/47; A61K38/17
Domestic Patent References:
| WO2001085986A2 | 2001-11-15 | |||
| WO2001025268A1 | 2001-04-12 | |||
| WO2001036975A1 | 2001-05-25 | |||
| WO2000022439A2 | 2000-04-20 | |||
| WO1998027213A1 | 1998-06-25 | |||
| WO2002000857A2 | 2002-01-03 | |||
| WO1992010200A1 | 1992-06-25 | |||
| WO2001086288A2 | 2001-11-15 | |||
| WO2002010771A1 | 2002-02-07 |
Foreign References:
| US5981218A | 1999-11-09 | |||
| DE19915485A1 | 2000-10-19 |
Other References:
SCHREIBER VALERIE ET AL: "Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions.", MOLECULAR MEDICINE (NEW YORK), vol. 4, no. 10, October 1998 (1998-10-01), pages 675 - 687, XP008019832, ISSN: 1076-1551
BUTT ELKE ET AL: "Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 18, 2 May 2003 (2003-05-02), pages 15601 - 15607, XP002248493, ISSN: 0021-9258
BUTT ELKE ET AL: "Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 18, 2 May 2003 (2003-05-02), pages 15601 - 15607, XP002248493, ISSN: 0021-9258
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