Title:
METHOD FOR DISTINGUISHING BETWEEN PROSTATE CANCER AND PROSTATIC HYPERPLASIA
Document Type and Number:
WIPO Patent Application WO/2015/068851
Kind Code:
A1
Abstract:
Provided is a method for distinguishing between prostate cancer and prostatic hyperplasia which has hereto been difficult to achieve. By measuring the quantity of MUC1, which contains sugar chains of cancer-associated structures, it is possible to distinguishing between prostate cancer and prostatic hyperplasia. The present invention provides a method for distinguishing between prostate cancer and prostatic hyperplasia from a value obtained by measuring MUC1 having, inside the same molecule, sugar chains of cancer-associated structures such as Neu5Acα2→3Galβ1→3GalNAcα-, and sugar chains of cancer-associated structures such as Neu5Acα2→3Galβ1→3(Neu5Acα2→6)GalNAcα-, by sandwich assay etc. using two antibodies.
Inventors:
NAKATA DAISUKE (JP)
Application Number:
PCT/JP2014/079863
Publication Date:
May 14, 2015
Filing Date:
November 11, 2014
Export Citation:
Assignee:
TOSOH CORP (JP)
SHIONOGI & CO (JP)
SHIONOGI & CO (JP)
International Classes:
G01N33/574
Domestic Patent References:
| WO2011052244A1 | 2011-05-05 |
Foreign References:
| JP2003519096A | 2003-06-17 | |||
| JP2012255736A | 2012-12-27 | |||
| JP2011038952A | 2011-02-24 | |||
| US20080071148A1 | 2008-03-20 | |||
| JP2013156245A | 2013-08-15 |
Other References:
XIONG CHENG-YI ET AL.: "Development of tumor targeting anti-MUC-I multimer: effects of di- scFv unpaired cysteine location on PEGylation and tumor binding", PROTEIN ENG DES SEL, vol. 19, no. 8, 2006, pages 359 - 367
CHANDRASEKARAN E. V. ET AL.: "Analysis of the Specificity of Sialyltransferases toward Mucin Core 2, Globo, and Related Structures. Identification of the Sialylation Sequence and the Effects of Sulfate, Fucose, Methyl, and Fluoro Substituents of the Carbohydrate Chain in the Biosynthesis of Selectin and Siglec Ligands, and Novel", BIOCHEMISTRY, vol. 44, no. 47, 2005, pages 15619 - 15635
CHANDRASEKARAN E. V. ET AL.: "Analysis of the Specificity of Sialyltransferases toward Mucin Core 2, Globo, and Related Structures. Identification of the Sialylation Sequence and the Effects of Sulfate, Fucose, Methyl, and Fluoro Substituents of the Carbohydrate Chain in the Biosynthesis of Selectin and Siglec Ligands, and Novel", BIOCHEMISTRY, vol. 44, no. 47, 2005, pages 15619 - 15635
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Aoki 篤 (JP)
Aoki 篤 (JP)
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