Title:
METHOD FOR EVALUATING FUTURE RISK OF OCCURRENCE OF CEREBRAL AND CARDIOVASCULAR EVENT, CALCULATION METHOD, EVALUATION DEVICE, CALCULATION DEVICE, EVALUATION PROGRAM, CALCULATION PROGRAM, STORAGE MEDIUM, EVALUATION SYSTEM, AND TERMINAL DEVICE
Document Type and Number:
WIPO Patent Application WO/2020/158828
Kind Code:
A1
Abstract:
In the present embodiment, the future risk of the occurrence of cerebral and cardiovascular events in a subject is evaluated using a concentration value of at least one amino acid among Gly, Cit, Trp, Met, and Val in blood of the subject and a value calculated using the Cox proportional hazard model including a variable for which the concentration value is substituted.
Inventors:
YAMAMOTO HIROSHI (JP)
TAKESHITA MASAMICHI (JP)
IMAIZUMI AKIRA (JP)
KAGEYAMA YOKO (JP)
MURAMATSU TAKAHIKO (JP)
TABARA YASUHARU (JP)
MATSUDA FUMIHIKO (JP)
TAKESHITA MASAMICHI (JP)
IMAIZUMI AKIRA (JP)
KAGEYAMA YOKO (JP)
MURAMATSU TAKAHIKO (JP)
TABARA YASUHARU (JP)
MATSUDA FUMIHIKO (JP)
Application Number:
PCT/JP2020/003269
Publication Date:
August 06, 2020
Filing Date:
January 29, 2020
Export Citation:
Assignee:
AJINOMOTO KK (JP)
UNIV KYOTO (JP)
UNIV KYOTO (JP)
International Classes:
G01N33/48; G01N33/68
Domestic Patent References:
| WO2016056631A1 | 2016-04-14 | |||
| WO2014168125A1 | 2014-10-16 |
Foreign References:
| JP2013178238A | 2013-09-09 | |||
| JP2012520463A | 2012-09-06 | |||
| JP2016075644A | 2016-05-12 | |||
| US20110104818A1 | 2011-05-05 |
Other References:
KUME, SHINJI: "Predictive properties of plasma amino acid profile for cardiovascular disease in patients with type 2 diabetes", PLOS ONE, vol. 9, no. 6, 4 June 2014 (2014-06-04), pages e101219, XP055141911
DHAR, I.: "Plasma methionine and risk of acute myocardial infarction: effect modification by established risk factors", ATHEROSCLEROSIS, vol. 272, May 2018 (2018-05-01), pages 175 - 181, XP055726020
KUME, SHINJI ET AL.: "Exploration of usefulness of plasma amino acid fractionation analysis ''amino index technology'' as a predictive index of cerebral and cardiovascular events in type 2 diabetic patients", DIABETIC COMPLICATIONS, vol. 27, no. 1, 20 August 2013 (2013-08-20), pages 164
WANG, X. X.: "Metabolic characterization of myocardial infarction using GC-MS-based tissue metabolomics", INTERNATIONAL HEART JOURNAL, vol. 58, no. 3, 2017, pages 441 - 446, XP055726021
TERAMOTO, TOMOHIKO ET AL.: "Influence of plasma homocysteine level on the prognosis of patients with coronary artery disease", JAPANESE JOURNAL OF APPLIED PHYSIOLOGY, vol. 34, no. 5-6, 1 December 2004 (2004-12-01), pages 269 - 273
DHAR, I.: "Plasma methionine and risk of acute myocardial infarction: effect modification by established risk factors", ATHEROSCLEROSIS, vol. 272, May 2018 (2018-05-01), pages 175 - 181, XP055726020
KUME, SHINJI ET AL.: "Exploration of usefulness of plasma amino acid fractionation analysis ''amino index technology'' as a predictive index of cerebral and cardiovascular events in type 2 diabetic patients", DIABETIC COMPLICATIONS, vol. 27, no. 1, 20 August 2013 (2013-08-20), pages 164
WANG, X. X.: "Metabolic characterization of myocardial infarction using GC-MS-based tissue metabolomics", INTERNATIONAL HEART JOURNAL, vol. 58, no. 3, 2017, pages 441 - 446, XP055726021
TERAMOTO, TOMOHIKO ET AL.: "Influence of plasma homocysteine level on the prognosis of patients with coronary artery disease", JAPANESE JOURNAL OF APPLIED PHYSIOLOGY, vol. 34, no. 5-6, 1 December 2004 (2004-12-01), pages 269 - 273
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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