Title:
METHOD FOR IDENTIFYING ANTIMICROBIAL COMPOUNDS AND DETERMINING ANTIBIOTIC SENSITIVITY
Document Type and Number:
WIPO Patent Application WO/2012/021802
Kind Code:
A3
Abstract:
Provided herein are improved methods of characterizing antibiotic agents according to the effect the antibiotic agent has on a bacterial cell. This allows for rapid screening of potential antibiotic agents, e.g., for improved antibiotics, and classification of antibiotic agents. The present techniques also allow for profiling of bacterial strains for susceptibility of antibiotic agents and, e.g., determining which are most susceptible to particular modes of action.
Inventors:
POGLIANO JOSEPH (US)
POGLIANO KIT (US)
POGLIANO KIT (US)
Application Number:
PCT/US2011/047582
Publication Date:
May 18, 2012
Filing Date:
August 12, 2011
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
POGLIANO JOSEPH (US)
POGLIANO KIT (US)
POGLIANO JOSEPH (US)
POGLIANO KIT (US)
International Classes:
C12Q1/18; C12Q1/04
Foreign References:
| US20050048599A1 | 2005-03-03 | |||
| US6534278B1 | 2003-03-18 | |||
| US20030017521A1 | 2003-01-23 |
Other References:
KAYE, J. ET AL.: "Cytological aspects of antimicrobial antibiosis. III. Cytologically Distinguishable stages in antibiotic action of colistin sulfate on Escherichia coli", JOURNAL OF BACTERIOLOGY., vol. 86, September 1963 (1963-09-01), pages 536 - 543
SILVER, L. L. ET AL.: "Does the cell wall of bacteria remain a viable source of targets for novel antibiotics?", BIOCHEMICAL PHARMACOLOGY., vol. 71, no. 7, 14 November 2005 (2005-11-14), pages 996 - 1005, XP025043158, DOI: doi:10.1016/j.bcp.2005.10.029
STOKES, N. R. ET AL.: "Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, 20 September 2005 (2005-09-20), pages 39709 - 39715, XP008143582
See also references of EP 2603601A4
SILVER, L. L. ET AL.: "Does the cell wall of bacteria remain a viable source of targets for novel antibiotics?", BIOCHEMICAL PHARMACOLOGY., vol. 71, no. 7, 14 November 2005 (2005-11-14), pages 996 - 1005, XP025043158, DOI: doi:10.1016/j.bcp.2005.10.029
STOKES, N. R. ET AL.: "Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, 20 September 2005 (2005-09-20), pages 39709 - 39715, XP008143582
See also references of EP 2603601A4
Attorney, Agent or Firm:
JOHNS, Carol P. et al. (Two Embarcadero Center 8th Floo, San Francisco California, US)
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