Title:
METHOD FOR IDENTIFYING SUBSTANCES WHICH POSITIVELY INFLUENCE INFLAMMATORY CONDITIONS OF CHRONIC INFLAMMATORY AIRWAY DISEASES
Document Type and Number:
WIPO Patent Application WO2002052269
Kind Code:
A3
Abstract:
The present invention relates to UDD-proteins in involved in inflammatory processes and the modulation of the function of such an UDD-protein in order to positively influence inflammatory diseases.
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Inventors:
JUNG BIRGIT (DE)
MUELLER STEFAN (DE)
KRAUT NORBERT (AT)
MUELLER STEFAN (DE)
KRAUT NORBERT (AT)
Application Number:
PCT/EP2001/014831
Publication Date:
March 20, 2003
Filing Date:
December 15, 2001
Export Citation:
Assignee:
BOEHRINGER INGELHEIM PHARMA (DE)
JUNG BIRGIT (DE)
MUELLER STEFAN (DE)
KRAUT NORBERT (AT)
JUNG BIRGIT (DE)
MUELLER STEFAN (DE)
KRAUT NORBERT (AT)
International Classes:
A61K38/17; A61P11/00; C12Q1/37; G01N33/50; (IPC1-7): G01N33/68; A61P11/00
Domestic Patent References:
| WO2000055173A1 | 2000-09-21 | |||
| WO1996032105A1 | 1996-10-17 | |||
| WO1999001567A2 | 1999-01-14 |
Other References:
ADAMS JULIAN ET AL: "Novel inhibitors of the proteasome and their therapeutic use in inflammation.", ANNUAL REPORTS IN MEDICINAL CHEMISTRY, vol. 31, 1996, 1996 Academic Press, Inc.;Academic Press Ltd. 1250 Sixth Ave., San Diego, California 92101, USA; 14 Belgrave Square, 24-28 Oval Road, London NW1 70X, England, UK, pages 279 - 288, XP000791150, ISBN: 0-12-040531-8
ELOFSSON M ET AL: "TOWARDS SUBUNIT-SPECIFIC PROTEASOME INHIBITORS: SYNTHESIS AND EVALUATION OF PEPTIDE ALPHA',BETA'-EPOXYKETONES", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 6, no. 11, 1995, pages 811 - 822, XP001002198, ISSN: 1074-5521
MENG LIHAO ET AL: "Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 18, 31 August 1999 (1999-08-31), pages 10403 - 10408, XP002168150, ISSN: 0027-8424
SANSORES RAUL H ET AL: "Effect of exposure of guinea pigs to cigarette smoke on elastolytic activity of pulmonary macrophages.", CHEST, vol. 112, no. 1, 1997, pages 214 - 219, XP002217578, ISSN: 0012-3692
YAMANAKA YASUNARI ET AL: "Gene expression profiles of human small airway epithelial cells treated with low doses of 14- and 16-membered macrolides.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 287, no. 1, 14 September 2001 (2001-09-14), pages 198 - 203, XP002217579, ISSN: 0006-291X
ELOFSSON M ET AL: "TOWARDS SUBUNIT-SPECIFIC PROTEASOME INHIBITORS: SYNTHESIS AND EVALUATION OF PEPTIDE ALPHA',BETA'-EPOXYKETONES", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 6, no. 11, 1995, pages 811 - 822, XP001002198, ISSN: 1074-5521
MENG LIHAO ET AL: "Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 18, 31 August 1999 (1999-08-31), pages 10403 - 10408, XP002168150, ISSN: 0027-8424
SANSORES RAUL H ET AL: "Effect of exposure of guinea pigs to cigarette smoke on elastolytic activity of pulmonary macrophages.", CHEST, vol. 112, no. 1, 1997, pages 214 - 219, XP002217578, ISSN: 0012-3692
YAMANAKA YASUNARI ET AL: "Gene expression profiles of human small airway epithelial cells treated with low doses of 14- and 16-membered macrolides.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 287, no. 1, 14 September 2001 (2001-09-14), pages 198 - 203, XP002217579, ISSN: 0006-291X
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