Title:
METHOD FOR INACTIVATING GENE OF PORCINE ENDOGENOUS RETROVIRUS AND COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/075154
Kind Code:
A1
Abstract:
The present application relates to a composition capable of artificially manipulating a PERV genome existing in multiple copies in the genome of a porcine cell, and a method for inactivating PERV using same.
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Inventors:
KOO OK JAE (KR)
YUM SOO YOUNG (KR)
YUM SOO YOUNG (KR)
Application Number:
PCT/KR2022/014077
Publication Date:
May 04, 2023
Filing Date:
September 21, 2022
Export Citation:
Assignee:
TOOLGEN INC (KR)
International Classes:
C12N7/00; A01K67/027; C12N9/22; C12N9/78; C12N15/113; C12N15/90
Domestic Patent References:
| WO2019005886A1 | 2019-01-03 |
Foreign References:
| KR20080025172A | 2008-03-19 |
Other References:
XIE JINGKE, GE WEIKAI, LI NAN, LIU QISHUAI, CHEN FANGBING, YANG XIAOYU, HUANG XINGYUN, OUYANG ZHEN, ZHANG QUANJUN, ZHAO YU, LIU ZH: "Efficient base editing for multiple genes and loci in pigs using base editors", NATURE COMMUNICATIONS, vol. 10, no. 1, 28 June 2019 (2019-06-28), UK, pages 2852, XP055905014, ISSN: 2041-1723, DOI: 10.1038/s41467-019-10421-8
LI ZHIFANG, DUAN XIAOYUE, AN XIAOMENG, FENG TAO, LI PAN, LI LINLIN, LIU JUN, WU PANXUE, PAN DENGKE, DU XUGUANG, WU SEN: "Efficient RNA-guided base editing for disease modeling in pigs", CELL DISCOVERY, vol. 4, no. 1, XP093060102, DOI: 10.1038/s41421-018-0065-7
SMITH CORY J, CASTANON OSCAR, SAID KHALED, VOLF VERENA, KHOSHAKHLAGH PARASTOO, HORNICK AMANDA, FERREIRA RAPHAEL, WU CHUN-TING, GÜE: "Enabling large-scale genome editing at repetitive elements by reducing DNA nicking", NUCLEIC ACIDS RESEARCH, vol. 48, no. 9, 21 May 2020 (2020-05-21), GB , pages 5183 - 5195, XP093060105, ISSN: 0305-1048, DOI: 10.1093/nar/gkaa239
YUM SOO-YOUNG, JANG GOO, KOO OKJAE: "Target-AID-Mediated Multiplex Base Editing in Porcine Fibroblasts", 21 September 2021 (2021-09-21), XP093060113, DOI: 10.20944/preprints202109.0362.v1
LI ZHIFANG, DUAN XIAOYUE, AN XIAOMENG, FENG TAO, LI PAN, LI LINLIN, LIU JUN, WU PANXUE, PAN DENGKE, DU XUGUANG, WU SEN: "Efficient RNA-guided base editing for disease modeling in pigs", CELL DISCOVERY, vol. 4, no. 1, XP093060102, DOI: 10.1038/s41421-018-0065-7
SMITH CORY J, CASTANON OSCAR, SAID KHALED, VOLF VERENA, KHOSHAKHLAGH PARASTOO, HORNICK AMANDA, FERREIRA RAPHAEL, WU CHUN-TING, GÜE: "Enabling large-scale genome editing at repetitive elements by reducing DNA nicking", NUCLEIC ACIDS RESEARCH, vol. 48, no. 9, 21 May 2020 (2020-05-21), GB , pages 5183 - 5195, XP093060105, ISSN: 0305-1048, DOI: 10.1093/nar/gkaa239
YUM SOO-YOUNG, JANG GOO, KOO OKJAE: "Target-AID-Mediated Multiplex Base Editing in Porcine Fibroblasts", 21 September 2021 (2021-09-21), XP093060113, DOI: 10.20944/preprints202109.0362.v1
Attorney, Agent or Firm:
IPLAY PATENT LAW FIRM (KR)
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