Title:
METHOD FOR INDUCING AN IMMUNE RESPONSE TO POLYSACCHARIDE BACTERIAL ANTIGENS AND TO PROTEIN STRUCTURES OF VIRUS CAPSIDS
Document Type and Number:
WIPO Patent Application WO2002056909
Kind Code:
A3
Abstract:
The invention concerns an immunogenic composition, in a pharmaceutically acceptable carrier, for specifically stimulating a sub-population of B M<+>D<+>CD27<+> cells so as to provide T-independent anti-bacterial response in said cells. The invention also concerns the use for producing T-independent anti-bacterial immune responses in subjects infected or susceptible of being infected by polysaccharide bacteria (streptococcus, meningococcus, pneumococcus, hemophilus influenza) or by protein capsid viruses (poliovirus, encephalomyocarditis virus, influenza virus).
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Inventors:
REYNAUD CLAUDE-AGNES (FR)
WEILL JEAN-CLAUDE (FR)
WEILL JEAN-CLAUDE (FR)
Application Number:
PCT/FR2002/000240
Publication Date:
October 30, 2003
Filing Date:
January 22, 2002
Export Citation:
Assignee:
INST NECKER (FR)
REYNAUD CLAUDE-AGNES (FR)
WEILL JEAN-CLAUDE (FR)
REYNAUD CLAUDE-AGNES (FR)
WEILL JEAN-CLAUDE (FR)
International Classes:
A61K39/00; A61K39/085; A61K39/095; A61K39/102; A61K39/39; A61P31/00; A61P37/00; C12Q1/02; C12Q1/68; G01N33/569; G01N33/53; (IPC1-7): A61K39/39; C12Q1/02; C12Q1/68; G01N33/53; A61P31/00; A61P37/00
Domestic Patent References:
| WO1999064603A2 | 1999-12-16 | |||
| WO1996012190A2 | 1996-04-25 |
Other References:
KLEIN U ET AL: "Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (Memory) B cells.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 188, no. 9, 2 November 1998 (1998-11-02), pages 1679 - 1689, XP002182727
TANGYE S G ET AL: "Identification of functional human splenic memory B cells by expression of CD148 and CD27.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 188, no. 9, 2 November 1998 (1998-11-02), pages 1691 - 1703, XP002182726
AGEMATSU K: "Memory B cells and CD27.", HISTOLOGY AND HISTOPATHOLOGY, vol. 15, no. 2, April 2000 (2000-04-01), pages 573 - 576, XP001031446
AGEMATSU K ET AL: "B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 27, no. 8, August 1997 (1997-08-01), pages 2073 - 2079, XP001031448, ISSN: 0014-2980
AGEMATSU K ET AL: "Absence of IgD-CD27+ memory B cell population in X-linked hyper-IgM syndrome.", JOURNAL OF CLINICAL INVESTIGATION, vol. 102, no. 4, 15 August 1998 (1998-08-15), pages 853 - 860, XP002182728
WELLER S ET AL: "CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 1166 - 1170, XP002182729
FAILI A ET AL: "AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.", NATURE IMMUNOLOGY, vol. 3, no. 9, September 2002 (2002-09-01), pages 815 - 821, XP008014204, ISSN: 1529-2908
TANGYE S G ET AL: "Identification of functional human splenic memory B cells by expression of CD148 and CD27.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 188, no. 9, 2 November 1998 (1998-11-02), pages 1691 - 1703, XP002182726
AGEMATSU K: "Memory B cells and CD27.", HISTOLOGY AND HISTOPATHOLOGY, vol. 15, no. 2, April 2000 (2000-04-01), pages 573 - 576, XP001031446
AGEMATSU K ET AL: "B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 27, no. 8, August 1997 (1997-08-01), pages 2073 - 2079, XP001031448, ISSN: 0014-2980
AGEMATSU K ET AL: "Absence of IgD-CD27+ memory B cell population in X-linked hyper-IgM syndrome.", JOURNAL OF CLINICAL INVESTIGATION, vol. 102, no. 4, 15 August 1998 (1998-08-15), pages 853 - 860, XP002182728
WELLER S ET AL: "CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 1166 - 1170, XP002182729
FAILI A ET AL: "AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.", NATURE IMMUNOLOGY, vol. 3, no. 9, September 2002 (2002-09-01), pages 815 - 821, XP008014204, ISSN: 1529-2908
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