Title:
METHOD FOR INDUCING T CELL DIFFERENTIATION, METHOD FOR PRODUCING T CELLS, T CELLS, PHARMACEUTICAL COMPOSITION, AND SCREENING METHOD
Document Type and Number:
WIPO Patent Application WO/2013/161408
Kind Code:
A1
Abstract:
Provided is a method for inducing differentiation of CD4-CD8αα+ T cells. One or multiple embodiments pertain to a method for inducing differentiation of CD4-CD8αα+ T cells from CD4+CD8-T cells, the method comprising in vitro cultivation of CD4+CD8- T cells under conditions wherein IL-2, TGF-β1, and atRA are present.
Inventors:
SUGAI MANABU
SHIMIZU AKIRA
NAMBU YUKIKO
SHIMIZU AKIRA
NAMBU YUKIKO
Application Number:
PCT/JP2013/056758
Publication Date:
October 31, 2013
Filing Date:
March 12, 2013
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12N5/0783; A61K35/12; A61K35/14; A61K35/17; A61P31/12; A61P35/00; A61P37/02; C12Q1/02
Other References:
RUST,C. ET AL.: "PHENOTYPICAL AND FUNCTIONAL CHARACTERIZATION OF SMALL INTESTINAL TCR-GAMMA- DELTA-POSITIVE T CELLS IN COELIAC DISEASE", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, vol. 35, no. 4, 1992, pages 459 - 468
SINKORA, M. ET AL.: "Development of .GAMMA.. DELTA. thymocyte subsets during prenatal and postnatal ontogeny", IMMUNOLOGY, vol. 115, no. 4, 2005, pages 544 - 555
TANG,X. ET AL.: "Anti-TCR antibody treatment activates a novel population of nonintestinal CD8 alpha alpha+TCR alpha beta(+) regulatory T cells and prevents experimental autoimmune encephalomyelitis", JOURNAL OF IMMUNOLOGY, vol. 178, no. 10, 2007, pages 6043 - 6050
NIKOLOVA,M. ET AL.: "Isolation of a CD8alphaalpha+ CD4- tumour T-cell clone with cytotoxic activity from a CD4+ CD8- cutaneous T-cell lymphoma", BRITISH JOURNAL OF DERMATOLOGY, vol. 148, no. 1, 2003, pages 24 - 29
NAMBU Y ET AL.: "In situ differentiation of CD8aa T cells from CD4 T cells in peripheral lymphoid tissues.", SCI REP., vol. 2, no. 642, pages 1 - 11
SINKORA, M. ET AL.: "Development of .GAMMA.. DELTA. thymocyte subsets during prenatal and postnatal ontogeny", IMMUNOLOGY, vol. 115, no. 4, 2005, pages 544 - 555
TANG,X. ET AL.: "Anti-TCR antibody treatment activates a novel population of nonintestinal CD8 alpha alpha+TCR alpha beta(+) regulatory T cells and prevents experimental autoimmune encephalomyelitis", JOURNAL OF IMMUNOLOGY, vol. 178, no. 10, 2007, pages 6043 - 6050
NIKOLOVA,M. ET AL.: "Isolation of a CD8alphaalpha+ CD4- tumour T-cell clone with cytotoxic activity from a CD4+ CD8- cutaneous T-cell lymphoma", BRITISH JOURNAL OF DERMATOLOGY, vol. 148, no. 1, 2003, pages 24 - 29
NAMBU Y ET AL.: "In situ differentiation of CD8aa T cells from CD4 T cells in peripheral lymphoid tissues.", SCI REP., vol. 2, no. 642, pages 1 - 11
Attorney, Agent or Firm:
IKEUCHI SATO & PARTNER PATENT ATTORNEYS (JP)
Patent business corporation Ikeuchi and Sato and partners (JP)
Patent business corporation Ikeuchi and Sato and partners (JP)
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