Title:
METHOD FOR MANUFACTURING HIGH PURITY (S)-METOPROLOL
Document Type and Number:
WIPO Patent Application WO/2013/141437
Kind Code:
A1
Abstract:
The present invention relates to a method for manufacturing (S)-metoprolol which is used as a depressant, and more specifically, to a novel method for effectively manufacturing high purity (S)-metoprolol, comprising the steps of: carrying out a condensation reaction of (R)-epichlorohydrin and 4-(2-methoxyethyl) phenol, which are starting materials, by using a chiral salen catalyst under a very mild condition in which racemization is suppressed; carrying out an epoxidation reaction in the presence of a base; and carrying out a condensation reaction with isopropyl amine.
Inventors:
KIM WON-SUP (KR)
CHOI HOON (KR)
KIM KWANG-SUB (KR)
HAN CHY-HYOUNG (KR)
CHO KWANG-JIN (KR)
CHOI HOON (KR)
KIM KWANG-SUB (KR)
HAN CHY-HYOUNG (KR)
CHO KWANG-JIN (KR)
Application Number:
PCT/KR2012/002975
Publication Date:
September 26, 2013
Filing Date:
April 19, 2012
Export Citation:
Assignee:
RSTECH CO LTD (KR)
KIM WON-SUP (KR)
CHOI HOON (KR)
KIM KWANG-SUB (KR)
HAN CHY-HYOUNG (KR)
CHO KWANG-JIN (KR)
KIM WON-SUP (KR)
CHOI HOON (KR)
KIM KWANG-SUB (KR)
HAN CHY-HYOUNG (KR)
CHO KWANG-JIN (KR)
International Classes:
C07C213/10; A61K31/135; A61K31/138; A61P9/12; C07C215/04
Domestic Patent References:
| WO2007141593A2 | 2007-12-13 |
Foreign References:
| US6252113B1 | 2001-06-26 | |||
| US20050107635A1 | 2005-05-19 | |||
| KR100332399B1 | 2002-04-13 | |||
| US5362757A | 1994-11-08 | |||
| US5034535A | 1991-07-23 |
Attorney, Agent or Firm:
AJU Kim Chang&Lee (KR)
특허법인 아주양헌 (KR)
특허법인 아주양헌 (KR)
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