Title:
METHOD FOR THE PREDICTION OF PREECLAMPSIA AND OTHER DISEASES
Document Type and Number:
WIPO Patent Application WO2001077675
Kind Code:
A3
Abstract:
The invention disclosed is a process for determining the cytoprotective activity of plasma that prevents the destruction of endothelial cells and forestalls the development of a number of diseases such as atherosclerosis, preeclampsia, edema, nephrotic syndrome, and stroke. The present invention includes a method of diagnosing a patient's proclivity to develop a disease having a correlation to a reduction in the concentration of pI 5.6 albumin in the plasma by determining a value indicative of the concentration of the pI. 5.6 albumint that is not bound to VLDL ("free pI 5.6 albumin") in the patient's blood serum. The preferred embodiment of the process utilizes in vitro methods to obtain an indicator of the free pI. 5.6 albumin instead of directly measuring the concentration of the free pI 5.6 albumin.
Inventors:
ARBOGAST BRADLEY W
Application Number:
PCT/US2001/007967
Publication Date:
March 07, 2002
Filing Date:
March 13, 2001
Export Citation:
Assignee:
ARBOGAST PHARMACEUTICALS INC (US)
International Classes:
G01N33/66; C12Q1/26; C12Q1/28; C12Q1/527; G01N33/50; G01N33/52; G01N33/53; G01N33/68; G01N33/92; (IPC1-7): G01N33/68; G01N33/92
Domestic Patent References:
| WO1990000365A1 | 1990-01-25 |
Foreign References:
| US5094943A | 1992-03-10 |
Other References:
ARBOGAST BRADLEY W ET AL: "Plasma factors that determine endothelial cell lepid toxicity in vitro correctly identify women with preeclampsia in early and late pregnancy", HYPERTENSION IN PREGNANCY, vol. 15, no. 3, 1996, pages 263 - 279, XP001041009
VIGNE JEAN-LOUIS ET AL: "Elevated nonesterified fatty acid concentrations in severe preeclampsia shift the isoelectric characteristics of plasma albumin.", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 82, no. 11, November 1997 (1997-11-01), pages 3786 - 3792, XP001041043, ISSN: 0021-972X
ARBOGAST BRADLEY W ET AL: "Which plasma factors bring about disturbance of endothelial function in pre-eclampsia?", LANCET (NORTH AMERICAN EDITION), vol. 343, no. 8893, 1994, pages 340 - 341, XP001039993, ISSN: 0099-5355
ENDRESEN M J ET AL: "INCREASED LIPOLYTIC ACTIVITY AND HIGH RATIO OF FREE FATTY ACIDS TO ALBUMIN IN SERA FROM WOMEN WITH PREECLAMPSIA LEADS TO TRIGLYCERIDE ACCUMULATION IN CULTURED ENDOTHELIAL CELLS", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 167, no. 2, 1992, pages 440 - 447, XP001040995, ISSN: 0002-9378
FRAYN KEITH N ET AL: "Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic heart diseases?", CLINICAL SCIENCE, vol. 90, 1996, London, pages 243 - 253, XP001041143
MASUO KAZUKO ET AL: "Nonesterified fatty acids (NEFAs) and triglyceride levels are the predictors of blood pressure elevation.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 33, no. 2 SUPPL. A, February 1999 (1999-02-01), 48th Annual Scientific Session of the American College of Cardiology;New Orleans, Louisiana, USA; March 7-10, 1999, pages 272A, XP001041069, ISSN: 0735-1097
EGAN B M ET AL: "Vascular effects of non-esterified fatty acids: Implications for the cardiovascular risk factor cluster.", PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol. 60, no. 5-6, May 1999 (1999-05-01), pages 411 - 420, XP001040974, ISSN: 0952-3278
VIGNE JEAN-LOUIS ET AL: "Elevated nonesterified fatty acid concentrations in severe preeclampsia shift the isoelectric characteristics of plasma albumin.", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 82, no. 11, November 1997 (1997-11-01), pages 3786 - 3792, XP001041043, ISSN: 0021-972X
ARBOGAST BRADLEY W ET AL: "Which plasma factors bring about disturbance of endothelial function in pre-eclampsia?", LANCET (NORTH AMERICAN EDITION), vol. 343, no. 8893, 1994, pages 340 - 341, XP001039993, ISSN: 0099-5355
ENDRESEN M J ET AL: "INCREASED LIPOLYTIC ACTIVITY AND HIGH RATIO OF FREE FATTY ACIDS TO ALBUMIN IN SERA FROM WOMEN WITH PREECLAMPSIA LEADS TO TRIGLYCERIDE ACCUMULATION IN CULTURED ENDOTHELIAL CELLS", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 167, no. 2, 1992, pages 440 - 447, XP001040995, ISSN: 0002-9378
FRAYN KEITH N ET AL: "Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic heart diseases?", CLINICAL SCIENCE, vol. 90, 1996, London, pages 243 - 253, XP001041143
MASUO KAZUKO ET AL: "Nonesterified fatty acids (NEFAs) and triglyceride levels are the predictors of blood pressure elevation.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 33, no. 2 SUPPL. A, February 1999 (1999-02-01), 48th Annual Scientific Session of the American College of Cardiology;New Orleans, Louisiana, USA; March 7-10, 1999, pages 272A, XP001041069, ISSN: 0735-1097
EGAN B M ET AL: "Vascular effects of non-esterified fatty acids: Implications for the cardiovascular risk factor cluster.", PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol. 60, no. 5-6, May 1999 (1999-05-01), pages 411 - 420, XP001040974, ISSN: 0952-3278
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