Title:
METHOD FOR PREPARING BORIC ACID ESTER BASED ON LITHIUM COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/118922
Kind Code:
A1
Abstract:
The present invention relates to the use of lithium compounds, and specifically relates to a method for preparing boric acid ester based on lithium compounds, comprising the following steps: in an inert gas atmosphere, mixing borane and carboxylic acid, adding a lithium compound catalyst, and then implementing a boron hydrogenation reaction to obtain a boric acid ester, the time of the boron hydrogenation reaction being 10-80 minutes and the temperature being room temperature; after the boron hydrogenation reaction is finished, bringing into contact with air to stop the reaction, depressurising the reaction solution to remove the solvent, and obtaining boron acid esters with different substituents; the lithium compounds are n-butyl lithium, lithium aniline, p-methyl lithium aniline, o-methyl lithium aniline, 2-methoxyaniline lithium, 4-methoxyaniline lithium, 2,6-dimethylaniline lithium, and 2,6-diisopropylaniline lithium. The lithium compounds disclosed in the present invention can catalyse the boron hydrogenation reaction of carboxylic acid and borane with high activity under room temperature conditions; the amount of lithium compound is 0.1-0.9% of the molar amount of carboxylic acid; compared to existing catalytic systems, using commercial reagent lithium compounds has mild reaction conditions, and the boric acid esters with different substituents can reach a yield of 99% under defined conditions, and can be further hydrolysed to obtain alcohol compounds.all
Inventors:
XUE MINGQIANG (CN)
XU XIAOJUAN (CN)
YAN DANDAN (CN)
KANG ZIHAN (CN)
HONG YUBIAO (CN)
SHEN QI (CN)
XU XIAOJUAN (CN)
YAN DANDAN (CN)
KANG ZIHAN (CN)
HONG YUBIAO (CN)
SHEN QI (CN)
Application Number:
PCT/CN2019/077386
Publication Date:
June 18, 2020
Filing Date:
March 07, 2019
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07F5/04; B01J31/02; B01J31/12
Foreign References:
| CN108659027A | 2018-10-16 | |||
| CN108654692A | 2018-10-16 | |||
| CN108409772A | 2018-08-17 |
Other References:
SESHA KISAN ET AL.: "Ruthenium-catalyzed Deoxygenative Hydroboration of Carboxylic Acids", ACS CATALYSIS, vol. 8, 26 April 2018 (2018-04-26), pages 4772 - 4776, XP055712325, DOI: 10.1021/acscatal.8b00900
XING, QIYI ET AL.: "Basic Organic Chemistry", 30 June 2005, HIGHER EDUCATION PRESS, CN, ISBN: 7-04-016637-2, article XING, QIYI ET AL.: "Reduction of Carboxylic Acid", pages: 582 - 583, XP009521536
XING, QIYI ET AL.: "Basic Organic Chemistry", 30 June 2005, HIGHER EDUCATION PRESS, CN, ISBN: 7-04-016637-2, article XING, QIYI ET AL.: "Reduction of Carboxylic Acid", pages: 582 - 583, XP009521536
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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