Title:
METHOD OF PREVENTING TPO ADSORPTION AND STABLE TPO-CONTAINING COMPOSITION
Document Type and Number:
WIPO Patent Application WO/1996/028182
Kind Code:
A1
Abstract:
A TPO-containing composition comprising a TPO protein having no sugar-chain portion and at least one pharmaceutically acceptable additive selected from the group consisting of proteins, cellulose derivatives, sulfated polysaccharides, surfactants, polyvinyl alcohol, macrogols and aminoacetic acid; and a method of preventing TPO from being adsorbed on a container wall by using the above composition containing such additives, thereby preventing the titer reduction caused by the adsorption.
Inventors:
OTSUKI NAOKI (JP)
Application Number:
PCT/JP1996/000636
Publication Date:
September 19, 1996
Filing Date:
March 14, 1996
Export Citation:
Assignee:
KIRIN BREWERY (JP)
OTSUKI NAOKI (JP)
OTSUKI NAOKI (JP)
International Classes:
A61K38/19; A61K47/26; A61K47/42; A61K47/44; A61K47/10; A61K47/18; A61K47/20; A61K47/32; A61K47/36; A61K47/38; (IPC1-7): A61K38/18; A61K38/19; A61K47/14; A61K47/18; A61K47/20; A61K47/24; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42
Domestic Patent References:
| WO1995018858A1 | 1995-07-13 | |||
| WO1995021919A2 | 1995-08-17 | |||
| WO1995021920A1 | 1995-08-17 | |||
| WO1995021626A1 | 1995-08-17 | |||
| WO1995026746A1 | 1995-10-12 |
Foreign References:
| JPH06313000A | 1994-11-08 | |||
| JP4506513A | ||||
| JPH0372429A | 1991-03-27 |
Other References:
See also references of EP 0815869A4
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