Title:
METHOD FOR PRODUCING CATECHIN CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2022/255417
Kind Code:
A1
Abstract:
Provided are: a method for efficiently producing a catechin conjugate by means of a semi-synthetic method; and a production intermediate of said catechin conjugate. The present invention provides a method for producing an allylated catechin protection derivative represented by formula (IV), said method including: allylating a hydroxyl group at the 3'- or 4'-position of a catechin compound represented by formula (I) to form an allylated catechin compound (II); subsequently benzylating a phenolic hydroxyl group to form a compound represented by formula (III); and subsequently subjecting the remaining hydroxyl groups to benzyloxycarbonylation.
Inventors:
SHIOI RYUTA (JP)
IWASHITA MASAZUMI (JP)
HASHIZUME KOHJIRO (JP)
IWASHITA MASAZUMI (JP)
HASHIZUME KOHJIRO (JP)
Application Number:
PCT/JP2022/022377
Publication Date:
December 08, 2022
Filing Date:
June 01, 2022
Export Citation:
Assignee:
KAO CORP (JP)
International Classes:
C07D311/62; C07H15/26
Foreign References:
| JP2014521702A | 2014-08-28 | |||
| CN104327034A | 2015-02-04 |
Other References:
MINGBAO ZHANG, G. ERIK JAGDMANN, MICHAEL VAN ZANDT, RYAN SHEELER, PAUL BECKETT, HAGEN SCHROETER: "Chemical Synthesis and Characterization of Epicatechin Glucuronides and Sulfates: Bioanalytical Standards for Epicatechin Metabolite Identification", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, vol. 76, no. 2, 22 February 2013 (2013-02-22), US , pages 157 - 169, XP055345870, ISSN: 0163-3864, DOI: 10.1021/np300568m
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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