Title:
METHOD OF PRODUCING HETEROCYCLIC CARBAMATES FROM AZA-HETEROCYCLIC COMPOUNDS AND CARBON DIOXIDE
Document Type and Number:
WIPO Patent Application WO2000058286
Kind Code:
A3
Abstract:
The invention relates to a method of producing heterocyclic carbamates of the general formula (I) by reacting aza-heterocyclic compounds with alkyl- or aryl-halides in the presence of carbon dioxide and alkali carbonate, and to new compounds of the general formula (I).
Inventors:
BARTH HUBERT (DE)
BETCHE HANS-JUERGEN (DE)
STEINER KLAUS (DE)
SCHNEIDER SIMON (DE)
BAYER ULRICH (DE)
WESTERMAYER MANFRED (DE)
WOLFSPERGER ULRIKE (DE)
BETCHE HANS-JUERGEN (DE)
STEINER KLAUS (DE)
SCHNEIDER SIMON (DE)
BAYER ULRICH (DE)
WESTERMAYER MANFRED (DE)
WOLFSPERGER ULRIKE (DE)
Application Number:
PCT/EP2000/001573
Publication Date:
March 15, 2001
Filing Date:
February 25, 2000
Export Citation:
Assignee:
GOEDECKE AG (DE)
BARTH HUBERT (DE)
BETCHE HANS JUERGEN (DE)
STEINER KLAUS (DE)
SCHNEIDER SIMON (DE)
BAYER ULRICH (DE)
WESTERMAYER MANFRED (DE)
WOLFSPERGER ULRIKE (DE)
BARTH HUBERT (DE)
BETCHE HANS JUERGEN (DE)
STEINER KLAUS (DE)
SCHNEIDER SIMON (DE)
BAYER ULRICH (DE)
WESTERMAYER MANFRED (DE)
WOLFSPERGER ULRIKE (DE)
International Classes:
C07D233/60; C07B61/00; C07D207/325; C07D209/08; C07D209/12; C07D209/18; C07D209/42; C07D209/86; C07D231/56; C07D233/61; C07D235/08; C07D491/04; (IPC1-7): C07D209/08; C07D207/32; C07D209/86; C07D231/56; C07D233/54; C07D235/06; C07D491/04
Domestic Patent References:
| WO1998004531A1 | 1998-02-05 |
Foreign References:
| US5792865A | 1998-08-11 | |||
| EP0628542A1 | 1994-12-14 |
Other References:
ALAN C. WEEDON ET AL.: "Removable groups for activiation of Indole Photochemistry", SYNTHESIS., vol. , - 1992, GEORG THIEME VERLAG. STUTTGART., DE, pages 95 - 100, XP002146001, ISSN: 0039-7881
VOLKER O. ILLI: "Phasentransfer-katalysierte N-Acylierung von Indol", SYNTHESIS., vol. 5, - 1979, GEORG THIEME VERLAG. STUTTGART., DE, pages 387 - 388, XP002146002, ISSN: 0039-7881
KEN J. BUTCHER: "Carbamate esters: a simple, mild method of formation", SYNLETT., - October 1994 (1994-10-01), THIEME VERLAG, STUTTGART., DE, pages 825 - 826, XP002144444, ISSN: 0936-5214
DALE L. BOGER ET AL: "Indole N-carbonyl compounds: preparation and coupling of indole-1-carboxylic acid anhydride", JOURNAL OF ORGANIC CHEMISTRY., vol. 52, - 1987, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 3934 - 3936, XP002154459, ISSN: 0022-3263
JOHN E. MACOR ET AL: "Neutral acylation ( protection ) of the indole nitrogen: a simple synthesis of indole-1-carboxylates, indole-1-thiocarboxylates and indole-1-carboxamides", TETRAHEDRON LETTERS., vol. 40, - 2 April 1999 (1999-04-02), ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 2733 - 2736, XP002154460, ISSN: 0040-4039
VOLKER O. ILLI: "Phasentransfer-katalysierte N-Acylierung von Indol", SYNTHESIS., vol. 5, - 1979, GEORG THIEME VERLAG. STUTTGART., DE, pages 387 - 388, XP002146002, ISSN: 0039-7881
KEN J. BUTCHER: "Carbamate esters: a simple, mild method of formation", SYNLETT., - October 1994 (1994-10-01), THIEME VERLAG, STUTTGART., DE, pages 825 - 826, XP002144444, ISSN: 0936-5214
DALE L. BOGER ET AL: "Indole N-carbonyl compounds: preparation and coupling of indole-1-carboxylic acid anhydride", JOURNAL OF ORGANIC CHEMISTRY., vol. 52, - 1987, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 3934 - 3936, XP002154459, ISSN: 0022-3263
JOHN E. MACOR ET AL: "Neutral acylation ( protection ) of the indole nitrogen: a simple synthesis of indole-1-carboxylates, indole-1-thiocarboxylates and indole-1-carboxamides", TETRAHEDRON LETTERS., vol. 40, - 2 April 1999 (1999-04-02), ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 2733 - 2736, XP002154460, ISSN: 0040-4039
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