Title:
METHOD AND REAGENT FOR DETECTING PANCREATIC CANCERS
Document Type and Number:
WIPO Patent Application WO/2021/246153
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for detecting pancreatic cancers and a reagent usable in the method. The method for detecting pancreatic cancers is characterized by measuring the amount of TFPI2 in body fluid sampled from a subject. Furthermore, an antibody that specifically recognizes TFPI2 processing polypeptide and intact TFPI2 is included in the reagent for detecting pancreatic cancers.
Inventors:
SHIBATA WATARU (JP)
TERAUCHI YASUO (JP)
ENDO ITARU (JP)
SHIMIZU YASUHIRO (JP)
OHTAKE NORIHISA (JP)
MYOBA SHOHEI (JP)
TERAUCHI YASUO (JP)
ENDO ITARU (JP)
SHIMIZU YASUHIRO (JP)
OHTAKE NORIHISA (JP)
MYOBA SHOHEI (JP)
Application Number:
PCT/JP2021/018724
Publication Date:
December 09, 2021
Filing Date:
May 18, 2021
Export Citation:
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
TOSOH CORP (JP)
TOSOH CORP (JP)
International Classes:
G01N33/574; C12N15/12; G01N27/62
Domestic Patent References:
| WO2019142636A1 | 2019-07-25 | |||
| WO2016084912A1 | 2016-06-02 | |||
| WO2019142636A1 | 2019-07-25 |
Foreign References:
| US20200095640A1 | 2020-03-26 | |||
| JP5224309B2 | 2013-07-03 | |||
| JP6074676B2 | 2017-02-08 |
Other References:
SEETHARAMAN BALASENTHIL, YING HUANG, SUYU LIU, TRACEY MARSH, JINYUN CHEN, SANFORD A. STASS, DEBRA KUKURUGA, RANDALL BRAND, NANYUE : "A Plasma Biomarker Panel to Identify Surgically Resectable Early-Stage Pancreatic Cancer", JOURNAL OF THE NATIONAL CANCER INSTITUTE, OXFORD UNIVERSITY PRESS, GB, vol. 109, no. 8, 1 August 2017 (2017-08-01), GB , XP055755071, ISSN: 0027-8874, DOI: 10.1093/jnci/djw341
S. BALASENTHIL, N. CHEN, S. T. LOTT, J. CHEN, J. CARTER, W. E. GRIZZLE, M. L. FRAZIER, S. SEN, A. M. KILLARY: "A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma", CANCER PREVENTION RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 4, no. 1, 1 January 2011 (2011-01-01), pages 137 - 149, XP055055351, ISSN: 19406207, DOI: 10.1158/1940-6207.CAPR-10-0025
HONDA, K ET AL., SCIENTIFIC REPORTS, vol. 5, pages 15921
J. PROTEOME RES., vol. 12, no. 10, 2013, pages 4340 - 4350
PLOS ONE, vol. 11, no. 10, 2016, pages e0165609
TAKADA, H. ET AL., CANCER GENETICS AND CYTOGENETICS, vol. 197, no. 1, 2010, pages 16
HIBI, K. ET AL., ANTICANCER RESEARCH, vol. 30, no. 4, 2010, pages 1205
SUN, F. K. ET AL., DIGESTIVE DISEASES AND SCIENCES, vol. 58, no. 4, 2013, pages 1010
NIGRO, C. L ET AL., JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 133, no. 5, 2013, pages 1278
SATO, N. ET AL.: "24", ONCOGENE, no. 5, 2005, pages 850
See also references of EP 4163634A1
S. BALASENTHIL, N. CHEN, S. T. LOTT, J. CHEN, J. CARTER, W. E. GRIZZLE, M. L. FRAZIER, S. SEN, A. M. KILLARY: "A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma", CANCER PREVENTION RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 4, no. 1, 1 January 2011 (2011-01-01), pages 137 - 149, XP055055351, ISSN: 19406207, DOI: 10.1158/1940-6207.CAPR-10-0025
HONDA, K ET AL., SCIENTIFIC REPORTS, vol. 5, pages 15921
J. PROTEOME RES., vol. 12, no. 10, 2013, pages 4340 - 4350
PLOS ONE, vol. 11, no. 10, 2016, pages e0165609
TAKADA, H. ET AL., CANCER GENETICS AND CYTOGENETICS, vol. 197, no. 1, 2010, pages 16
HIBI, K. ET AL., ANTICANCER RESEARCH, vol. 30, no. 4, 2010, pages 1205
SUN, F. K. ET AL., DIGESTIVE DISEASES AND SCIENCES, vol. 58, no. 4, 2013, pages 1010
NIGRO, C. L ET AL., JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 133, no. 5, 2013, pages 1278
SATO, N. ET AL.: "24", ONCOGENE, no. 5, 2005, pages 850
See also references of EP 4163634A1
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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