Title:
METHOD FOR REGULATING SURVIVAL AND MEMORY OF T HELPER 1 CELLS
Document Type and Number:
WIPO Patent Application WO/2011/116353
Kind Code:
A3
Abstract:
The present invention provides a method of inhibiting survival of T helper 1 (Thl) memory cells by contacting or administering a population of Thl cells with an agent that inhibits CD44 receptor expression or activation. The invention further provides a method of stimulating memory Thl cell survival comprising contacting or administering Thl cells with an agent that increases CD44 receptor activation or expression in the cells. The invention additionally provides a method of screening for agents capable of modulating Thl cell survival.
Inventors:
BRADLEY LINDA M (US)
Application Number:
PCT/US2011/029097
Publication Date:
January 12, 2012
Filing Date:
March 18, 2011
Export Citation:
Assignee:
SANFORD BURNHAM MED RES INST (US)
BRADLEY LINDA M (US)
BRADLEY LINDA M (US)
International Classes:
C12N5/0783; A61K39/395; A61P37/00; C12N5/02; G01N33/15; A61K39/00
Other References:
BAATEN ET AL.: "CD44 regulates survival and memory development in Th1 cells", IMMUNITY, vol. 32, 14 January 2010 (2010-01-14), pages 104 - 115
LESLEY ET AL.: "Hyaluronan binding function of CD44 is transiently activated on T cells during an in vivo immune response", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 180, July 1994 (1994-07-01), pages 383 - 387
PONTA ET AL.: "CD44: from adhesion molecules to signalling regulators", NATURE REVIEW MOLECULAR CELL BIOLOGY, vol. 4, January 2003 (2003-01-01), pages 33 - 45
LESLEY ET AL.: "Hyaluronan binding function of CD44 is transiently activated on T cells during an in vivo immune response", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 180, July 1994 (1994-07-01), pages 383 - 387
PONTA ET AL.: "CD44: from adhesion molecules to signalling regulators", NATURE REVIEW MOLECULAR CELL BIOLOGY, vol. 4, January 2003 (2003-01-01), pages 33 - 45
Attorney, Agent or Firm:
HAILE, Lisa, A. (4365 Executive DriveSuite 110, San Diego CA, US)
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