METHOD FOR SIMULTANEOUSLY DETECTING FLUORESCENCE AND RAMAN SIGNALS FOR MULTIPLE FLUORESCENCE AND RAMAN SIGNAL TARGETS, AND MEDICAL IMAGING DEVICE FOR SIMULTANEOUSLY DETECTING MULTIPLE TARGETS USING THE METHOD

WIPO Patent Application WO/2012/021015

A2

The present invention relates to a method for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets, and to a medical imaging device for simultaneously detecting multiple targets using the method. The method for simultaneously detecting fluorescence and Raman signals for multiple fluorescence and Raman signal targets according to one embodiment of the present invention comprises the following steps: injecting at least one marker particle consisting of Raman markers and receptors into the body of an animal, such as a human; irradiating a laser beam onto the body of the animal; and detecting the optical signals emitted by the marker particle after the irradiation of the laser beam separately as a fluorescence signal and a Raman signal. According to the present invention, the simultaneous detection of multiple targets may be performed even without individually scanning optical signals emitted by the marker particle. In addition, according to the present invention, as an examination may be performed by injecting surface-enhanced Raman marker particles, into which fluorescent components are introduced, into the body of the animal using a spray or the like, weak Raman signals may be augmented so as to obtain a more accurate diagnosis result in real time.

JEONG DAE HONG (KR)
KANG KEON WOOK (KR)
LEE DONG SOO (KR)
LEE YOON SIK (KR)
KIM GUN SUNG (KR)
JUN BONG HYUN (KR)
PAENG JIN CHUL (KR)
LEE HO YOUNG (KR)
LEE YUN SANG (KR)

PCT/KR2011/005915

February 16, 2012

August 11, 2011

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SNU R&DB FOUNDATION (KR)
JEONG DAE HONG (KR)
KANG KEON WOOK (KR)
LEE DONG SOO (KR)
LEE YOON SIK (KR)
KIM GUN SUNG (KR)
JUN BONG HYUN (KR)
PAENG JIN CHUL (KR)
LEE HO YOUNG (KR)
LEE YUN SANG (KR)

A61B1/00; A61B1/05; A61B5/00

US7285089B2	2007-10-23
JP2002136469A	2002-05-14
JP2009511175A	2009-03-19
US20080007716A1	2008-01-10
KR20100073308A	2010-07-01
KR20080011195A	2008-01-31
US7336990B2	2008-02-26
US20090023999A1	2009-01-22
US7447539B2	2008-11-04
US7336990B2	2008-02-26
US7383077B2	2008-06-03
KR100892629B1	2009-04-08
KR20100004458A	2010-01-13
KR20070014964A	2007-02-01

NANO LETTERS, vol. 7, no. 2, 2007, pages 351 - 356
PROC. SPIE, vol. 6009, 2005, pages 60090C
NANO LETTERS, vol. 5, no. 1, 2005, pages 49 - 54
KEREN ET AL., PNAS, vol. 105, 2008, pages 5844
See also references of EP 2604168A4

CHO, YOUNG HYUN (KR)
조영현 (KR)

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