Title:
A METHOD FOR STIMULATING THE IMMUNE SYSTEM
Document Type and Number:
WIPO Patent Application WO1999063975
Kind Code:
A3
Abstract:
Medicament comprising a combination of at least one inhibitor of the effect of a substance negatively effecting an immune response, the substance selected from the group consisting of TGF- beta and its receptors, VEGF and its receptors, interleukin 10 (IL-10) and its receptors, PGE2 and its receptors, wherein the inhibitor has a molecular weight of less than 100 kDa and at least one stimulator positively effecting an immune response.
Inventors:
SCHLINGENSIEPEN KARL-HERMANN (DE)
SCHLINGENSIEPEN REIMAR (DE)
BRYSCH WOLFGANG (DE)
SCHLINGENSIEPEN REIMAR (DE)
BRYSCH WOLFGANG (DE)
Application Number:
PCT/EP1999/004013
Publication Date:
August 03, 2000
Filing Date:
June 10, 1999
Export Citation:
Assignee:
BIOGNOSTIK GES (DE)
SCHLINGENSIEPEN KARL HERMANN (DE)
SCHLINGENSIEPEN REIMAR (DE)
BRYSCH WOLFGANG (DE)
SCHLINGENSIEPEN KARL HERMANN (DE)
SCHLINGENSIEPEN REIMAR (DE)
BRYSCH WOLFGANG (DE)
International Classes:
A61K31/7088; A61K31/7105; A61K38/00; A61K38/19; A61K38/20; A61K39/395; A61K45/06; A61K48/00; C12N15/09; A61P31/00; A61P35/00; A61P35/02; A61P37/02; C12N15/11; A61K39/00; (IPC1-7): A61K48/00; A61K31/70; A61K38/20; A61K38/19; C12N15/11
Domestic Patent References:
| WO1996002143A1 | 1996-02-01 | |||
| WO1994025588A2 | 1994-11-10 | |||
| WO1995000103A2 | 1995-01-05 |
Other References:
JACHIMCZAK P ET AL: "The effect of transforming growth factor-beta 2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma.", JOURNAL OF NEUROSURGERY, vol. 78, no. 6, June 1993 (1993-06-01), pages 944 - 951, XP000886109
SPEARMAN M ET AL: "Antisense oligodeoxyribonucleotide inhibition of TGF - beta 1 gene expression and alterations in the growth and malignant properties of mouse fibrosarcoma cells.", GENE, vol. 149, no. 1, 4 November 1994 (1994-11-04), pages 25 - 9, XP002089439
AKPORIAYE E. T., PARK J. A.: "CONCOMITANT EXPRESSION OF INTERFERON-Y AND ANTISENSE TGF-SS TRANSGENES ENHANCES THE IMMUNOGENICITY OF A MURINE MAMMARY CARCINOMA.", CANCER GENE THERAPY, APPLETON & LANGE, GB, vol. 04., no. 06., 20 November 1997 (1997-11-20), GB, pages 150, XP000886176, ISSN: 0929-1903
SPEARMAN M ET AL: "Antisense oligodeoxyribonucleotide inhibition of TGF - beta 1 gene expression and alterations in the growth and malignant properties of mouse fibrosarcoma cells.", GENE, vol. 149, no. 1, 4 November 1994 (1994-11-04), pages 25 - 9, XP002089439
AKPORIAYE E. T., PARK J. A.: "CONCOMITANT EXPRESSION OF INTERFERON-Y AND ANTISENSE TGF-SS TRANSGENES ENHANCES THE IMMUNOGENICITY OF A MURINE MAMMARY CARCINOMA.", CANCER GENE THERAPY, APPLETON & LANGE, GB, vol. 04., no. 06., 20 November 1997 (1997-11-20), GB, pages 150, XP000886176, ISSN: 0929-1903
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