METHOD OF TESTING NEUROTOXICITY OF POLIOVIRUS VACCINE

Title:

METHOD OF TESTING NEUROTOXICITY OF POLIOVIRUS VACCINE

Document Type and Number:

WIPO Patent Application WO/1995/025954

Kind Code:

A1

Abstract:

A method of testing the neurotoxicity of poliovirus vaccine by inoculating the vaccine into the spinal cord of a transgenic nonprimatial vertebrate having poliovirus receptor genes introduced thereinto.

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Inventors:

ABE SHINOBU (JP)
OTA YOSHIHIRO (JP)
HASHIZUME SO (JP)
KOIKE SATOSHI (JP)
NOMOTO AKIO (JP)
YONEKAWA HIROMICHI (JP)
TAYA CHOJI (JP)
NOMURA TATSUJI (JP)

Application Number:

PCT/JP1994/000451

Publication Date:

September 28, 1995

Filing Date:

March 18, 1994

Export Citation:

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Assignee:

JAPAN POLIOMYELITIS RES INST (JP)
CENTRAL INST EXPER ANIMALS (JP)
ABE SHINOBU (JP)
OTA YOSHIHIRO (JP)
HASHIZUME SO (JP)
KOIKE SATOSHI (JP)
NOMOTO AKIO (JP)
YONEKAWA HIROMICHI (JP)
TAYA CHOJI (JP)
NOMURA TATSUJI (JP)

International Classes:

A01K67/027; C07K14/705; C12N15/85; (IPC1-7): G01N33/15; A61K39/13; C12N15/41

Domestic Patent References:

WO1990010699A1

1990-09-20

Foreign References:

JPH04504200A	1992-07-30
JPH01503039A	1989-10-19
JPH05508554A	1993-12-02

Other References:

REN. R. ET AL., CELL, vol. 63, 1990, pages 353 - 362
KOIKE, S. ET AL., PROC. NAT'L. ACAD. SCI. USA., vol. 88, 1991, pages 951 - 955
See also references of EP 0701127A4

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