INTERNATIONALSEARCHREPORTintt cional Application No PCT/EP00/02031 C.(Continuation)DOCUMENTSCONSIDEREDTOBERELEVANT Category Citation of document,withindication,whereappropriate,oftherelevantpassag esRelevanttoclaimNo. XWO9411521A(BIOSTARINC)1,3,4,6, 26May1994(1994-05-26)12-23, citedintheapplication26,31-41 page14,line14-page15,line22 page16,line30-page17,line23 page23,line1-16 page23,line24-page24,line19 XDATABASEGENEMBL'Online!1-23,31, 16July1988(1988-07-16)32,34 HUNT,C.ANDMORIMOTO,R.I.:"Humanheat shockprotein(hsp70)gene,completecds" XP002144203 citedintheapplication AccessionM11717 -&HUNT,C.ANDMORIMOTO,R.I.: "Conservedfeaturesofeukaryotichsp-70 genesrevealeedbycomparisonwiththe nucleotidesequenceofhumanhsp-70" PROC.NATL.ACAD.SCI.USA, vol.82,no.19,1985,pages6455-6459, XP000929693 figure2 XMOSELEYPOPELETAL:"Heatstress1-5, regulatesthehuman70-kDaheat-shockgene12-23, throughthe3'-untranslatedregion."31-34 AMERICANJOURNALOFPHYSIOLOGY, vol.264,no.6PART1,1993,pages L533-L537,XP000925808 ISSN:0002-9513 figure4 APITTOLETIZIOETAL:"Roleoftheleader1-41 sequenceduringthermalrepressionof translationinmaize,tobacco,andcarrot protoplasts." PLANTPHYSIOLOGY(ROCKVILLE), vol.100,no.4,1992,pages1827-1833, XP000929495 ISSN:0032-0889 figures1,3 page1829,right-handcolumn-page1830, left-handcolumn table1 AUS5659122A(AUSTINGLENNDOUGLAS)1-41 19August1997(1997-08-19) seeEXAMPLE ___ 4 INTERNATIONALSEARCHREPORTm,.tionaiApplication No PCT/EP00/02031 C.(Continuation)DOCUMENTSCONSIDEREDTOBERELEVANT CategoryCitationofdocument,withindication,whereappropriate,o ftherelevantpassagesRelevanttoclaimNo. AHESSMARKAETAL:"Sequenceand1-41 structuredeterminantsofDrosophilaHsp70 mRNAtranslation:5'-UTRsecondary structurespecificallyinhibitsheatshock proteinmRNAtranslation." NUCLEICACIDSRESEARCH, vol.24,no.12,1996,pages2441-2449, XP002144202 ISSN:0305-1048 citedintheapplication thewholedocument ALIARAKOSCHARLESDETAL:"The1-41 translationefficiencyofovalbuminmRNA isdeterminedinpartbya5'-endhairpin structure." ARCHIVESOFBIOCHEMISTRYANDBIOPHYSICS, vol.315,no.1,1994,pages54-59, XP000925807 ISSN:0003-9861 page55,right-handcolumn,paragraph4 -page56,right-handcolumn,paragraph2; figure2 AJOSHICHANDRASHEKHARPETAL:"5'1-41 untranslatedleadersequencesof eukaryoticmRNAsencodingheatshock inducedproteins." NUCLEICACIDSRESEARCH, vol.23,no.4,1995,pages541-549, XP000929506 ISSN:0305-1048 figures1,2;tables2,3 4 FURTHER INFORMATION CONTINUED FROM PCT/ISA/210 Continuation of Box 1.2 Present claims 1-41 relate to a product by reference to a desirable characteristic or property, namely, to a DNA molecule that can be transcribed to provide an RNA having an untranslated region that provides an increased efficency of translation of a polypeptide when operably linked to a region encoding said polypeptide. The claims cover all products having this characteristic or property, whereas the application provides support within the meaning of Article 6 PCT and/or disclosure within the meaning of Article 5 PCT for only a very limited number of such products. In the present case, the claims so lack support, and the application so lacks disclosure, that a meaningful search over the whole of the claimed scope is impossible. Independent of the above reasoning, the claims also lack clarity (Article 6 PCT). An attempt is made to define the product by reference to a result to be achieved. Again, this lack of clarity in the present case is such as to render a meaningful search over the whole of the claimed scope impossible. Consequently, the search has been carried out for those parts of the claims which appear to be clear, supported and disclosed, namely those parts relating to the sequence of the human hsp70 gene encoding for the 5'-untranslated region of the human hsp70 mRNA.

The applicant's attention is drawn to the fact that claims, or parts of claims, relating to inventions in respect of which no international search report has been established need not be the subject of an international preliminary examination (Rule 66.1 (e) PCT). The applicant is advised that the EPO policy when acting as an International Preliminary Examining Authority is normally not to carry out a preliminary examination on matter which has not been searched. This is the case irrespective of whether or not the claims are amended following receipt of the search report or during any Chapter II procedure. INTERNATIONALSEARCHREPORT Intt. tional ApplicationNo informationonpatent{4 {9 memben PatentdocumentPublicationPatentfamily Publication citedinsearchreportdate member(s)date WO8700861A12-02-1987AU 604214 B 13-12-1990 AU 6286086 A 05-03-1987 EP 0231368 A 12-08-1987 ES 2003085 A 16-10-1988 NO 871328 A 30-03-1987 ZA 8605702 A 25-03-1987 WO9411521A26-05-1994US 5521084 A 28-05-1996 CA 2148492 A 26-05-1994 EP 0672156 A 20-09-1995 JP 8505283 T 11-06-1996 US 5981224 A 09-11-1999 US 5733745 A 31-03-1998 US5659122A19-08-1997US 5362865 A 08-11-1994 AU 7833494 A 22-03-1995 CA 2169854 A 09-03-1995 EP 0716709 A 19-06-1996 WO 9506742 A 09-03-1995