Title:
METHOD OF TREATING SEXUAL DISTURBANCES
Document Type and Number:
WIPO Patent Application WO2000040226
Kind Code:
A3
Abstract:
The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually therapeutic amount is from about 0.2 thru 8 mg/person/dose and where the sexually mating amount is from about 0.003 thru 0.2 mg/kg/dose.
Inventors:
MEGLASSON MARTIN DURHAM (US)
MCCALL ROBERT B (US)
MCCALL ROBERT B (US)
Application Number:
PCT/US1999/027951
Publication Date:
February 01, 2001
Filing Date:
December 20, 1999
Export Citation:
Assignee:
UPJOHN CO (US)
MEGLASSON MARTIN DURHAM (US)
MCCALL ROBERT B (US)
MEGLASSON MARTIN DURHAM (US)
MCCALL ROBERT B (US)
International Classes:
A61K31/201; A61K31/417; A61K31/4375; C07D471/06; A61K31/444; A61K31/47; A61K31/472; A61K31/4745; A61K31/475; A61K31/485; A61K31/519; A61K31/52; A61K31/535; A61K31/557; A61K38/00; A61K38/22; A61K45/00; A61P9/08; A61P15/00; A61P15/10; A61P21/02; C07D471/18; (IPC1-7): A61K31/4745; A61K45/06; A61P15/00
Domestic Patent References:
| WO1990015058A1 | 1990-12-13 | |||
| WO1995004056A1 | 1995-02-09 |
Foreign References:
| US6018046A | 2000-01-25 |
Other References:
DURHAM, ROBERT A. ET AL: "Effects of selective activation of dopamine D2 and D3 receptors on prolactin secretion and the activity of tuberoinfundibular dopamine neurons", EUR. J. PHARMACOL. (1997), 335(1), 37-42, 1997, XP000951475
HILDEBRANDT: "PSCHYREMBEL KLINISCHES WOERTERBUCH", WALTER DE GRUYTER, BERLIN, XP002149893, 24017
HEIER RICHARD F ET AL: "Synthesis and biological activity of (R)-5,6-dihydro-N,N-dimethyl-4H- imidazo(4,5,1-ij)quinolin-5-amine and its metabolites.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 5, 1997, pages 639 - 646, XP002149892, ISSN: 0022-2623
HILDEBRANDT: "PSCHYREMBEL KLINISCHES WOERTERBUCH", WALTER DE GRUYTER, BERLIN, XP002149893, 24017
HEIER RICHARD F ET AL: "Synthesis and biological activity of (R)-5,6-dihydro-N,N-dimethyl-4H- imidazo(4,5,1-ij)quinolin-5-amine and its metabolites.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 5, 1997, pages 639 - 646, XP002149892, ISSN: 0022-2623
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