Title:
METHODS AND COMPOSITIONS FOR ENHANCING INNATE IMMUNITY AND ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY
Document Type and Number:
WIPO Patent Application WO2005034979
Kind Code:
A3
Abstract:
Cationic liposomes with immunostimulatory nucleic acids are shown to stimulate the innate immune response, and synergistic combinations of such liposomal nucleic acids and therapeutic antibodies are provided to dramatically improve antibody dependent cellular cytotoxicity and target cell lysis.
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Inventors:
TAM YING K (CA)
CHIKH GHANIA (CA)
SEKIROV LAURA (CA)
BRODSKY IRINA (CA)
RANEY SAMEERSINGH G (CA)
CHIKH GHANIA (CA)
SEKIROV LAURA (CA)
BRODSKY IRINA (CA)
RANEY SAMEERSINGH G (CA)
Application Number:
PCT/IB2004/003317
Publication Date:
June 02, 2005
Filing Date:
October 11, 2004
Export Citation:
Assignee:
INEX PHARMACEUTICALS CORP (CA)
TAM YING K (CA)
CHIKH GHANIA (CA)
SEKIROV LAURA (CA)
BRODSKY IRINA (CA)
RANEY SAMEERSINGH G (CA)
TAM YING K (CA)
CHIKH GHANIA (CA)
SEKIROV LAURA (CA)
BRODSKY IRINA (CA)
RANEY SAMEERSINGH G (CA)
International Classes:
A61K9/127; A61K31/7088; A61K31/7115; A61K31/712; A61K38/00; A61K39/395; A61K45/06; C07K16/28; C07K16/30; C07K16/32; (IPC1-7): A61K39/395; A61K31/7115; A61K31/712; A61K9/127; A61P35/00; A61K38/00
Domestic Patent References:
| WO2003094829A2 | 2003-11-20 | |||
| WO2000056342A2 | 2000-09-28 | |||
| WO2003026688A1 | 2003-04-03 | |||
| WO1996002555A1 | 1996-02-01 | |||
| WO2001015726A2 | 2001-03-08 |
Other References:
LEONETTI C ET AL: "Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line", CANCER GENE THERAPY, NORWALK, CT, US, vol. 8, no. 6, June 2001 (2001-06-01), pages 459 - 468, XP002260435, ISSN: 0929-1903
SEMPLE^A S C ET AL: "Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 1510, no. 1-2, 9 February 2001 (2001-02-09), pages 152 - 166, XP004248775, ISSN: 0005-2736
MUI B ET AL: "Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND, US, vol. 298, no. 3, September 2001 (2001-09-01), pages 1185 - 1192, XP002224996, ISSN: 0022-3565
NORMANNO N ET AL: "Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth", ANNALS OF ONCOLOGY, KLUWER, DORDRECHT, NL, vol. 13, no. 1, January 2002 (2002-01-01), pages 65 - 72, XP002302015, ISSN: 0923-7534
CZUCZMAN M S ET AL: "PILOT STUDY OR RITUXAN IN COMBINATION WITH FLUDARABINE CHEMOTHERAPY IN PATIENTS WITH LOW-GRADE OR FOLLICULAR NON-HODGKIN'S LYMPHOMA", PROGRAM/PROCEEDINGS - AMERICAN SOCIETY OF CLINICAL ONCOLOGY, THE SOCIETY, US, vol. 18, 1999, pages 17A, XP001056194, ISSN: 1081-0641
SEMPLE^A S C ET AL: "Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 1510, no. 1-2, 9 February 2001 (2001-02-09), pages 152 - 166, XP004248775, ISSN: 0005-2736
MUI B ET AL: "Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND, US, vol. 298, no. 3, September 2001 (2001-09-01), pages 1185 - 1192, XP002224996, ISSN: 0022-3565
NORMANNO N ET AL: "Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth", ANNALS OF ONCOLOGY, KLUWER, DORDRECHT, NL, vol. 13, no. 1, January 2002 (2002-01-01), pages 65 - 72, XP002302015, ISSN: 0923-7534
CZUCZMAN M S ET AL: "PILOT STUDY OR RITUXAN IN COMBINATION WITH FLUDARABINE CHEMOTHERAPY IN PATIENTS WITH LOW-GRADE OR FOLLICULAR NON-HODGKIN'S LYMPHOMA", PROGRAM/PROCEEDINGS - AMERICAN SOCIETY OF CLINICAL ONCOLOGY, THE SOCIETY, US, vol. 18, 1999, pages 17A, XP001056194, ISSN: 1081-0641
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