Title:
METHODS AND COMPOSITIONS FOR TREATING VIRAL INFECTION
Document Type and Number:
WIPO Patent Application WO/2022/115536
Kind Code:
A3
Abstract:
The disclosure provides methods for treating or preventing coronavirus infection comprising administration of a therapeutically effective amount of lactoferrin or a therapeutically effective amount of a protein fusion comprising recombinant lactoferrin fused to the receptor binding domain of the SARS-CoV-2 spike protein. Also provided are methods for treating or preventing SARS-CoV-2 infection comprising co-administration of a therapeutically effective amount of lactoferrin and a second drug treatment, such as ivermectin. Also provided are methods for treating or preventing SARS-CoV-2 infection comprising co-administration of a therapeutically effective amount of lactoferrin and a second drug treatment, such as ivermectin.
Inventors:
HAN JANG HYUN (US)
RUTTER BILL (US)
SEO MI-YOUNG (KR)
RUTTER BILL (US)
SEO MI-YOUNG (KR)
Application Number:
PCT/US2021/060732
Publication Date:
July 07, 2022
Filing Date:
November 24, 2021
Export Citation:
Assignee:
AVIRUS INC (US)
International Classes:
A61K39/12; A61K38/40; A61P31/14; A61P37/02; C07K14/79; C12N15/62
Foreign References:
| CN111217917A | 2020-06-02 | |||
| US20110091543A1 | 2011-04-21 | |||
| US20150093382A1 | 2015-04-02 | |||
| US20160376321A1 | 2016-12-29 |
Other References:
ROMY FISCHER, HAJER DEBBABI, MICHEL DUBARRY, PROSPER BOYAKA, DANIEL TOME: "Regulation of physiological and pathological Th1 and Th2 responses by lactoferrin", BIOCHEMISTRY AND CELL BIOLOGY, vol. 84, no. 3, 1 June 2006 (2006-06-01), CA , pages 303 - 311, XP009544699, ISSN: 0829-8211, DOI: 10.1139/o06-058
MATTIA MIOTTO; LORENZO DI RIENZO; LEONARDO B\`O; ALBERTO BOFFI; GIANCARLO RUOCCO; EDOARDO MILANETTI: "Molecular mechanisms behind anti SARS-CoV-2 action of lactoferrin", ARXIV.ORG, CORNELL UNIVERSITY LIBRARY, 201 OLIN LIBRARY CORNELL UNIVERSITY ITHACA, NY 14853, 14 July 2020 (2020-07-14), 201 Olin Library Cornell University Ithaca, NY 14853 , XP081929706, DOI: 10.3389/fmolb.2021.607443
JIANSHE LANG, NING YANG, JIEJIE DENG, KANGTAI LIU, PENG YANG, GUIGEN ZHANG, CHENGYU JIANG, ROBERT GERAGHTY: "Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 6, no. 8, 1 August 2011 (2011-08-01), pages e23710, XP055765756, DOI: 10.1371/journal.pone.0023710
ABD ELWAKIL MAHMOUD M, MABROUK MOUSTAFA T, HELMY MAGED W, ABDELFATTAH ELSAYEDA-ZEINAB A, KHISTE SACHIN K, ELKHODAIRY KADRIA A, ELZ: "Inhalable lactoferrin–chondroitin nanocomposites for combined delivery of doxorubicin and ellagic acid to lung carcinoma", NANOMEDICINE, vol. 13, no. 16, 1 August 2018 (2018-08-01), GB , pages 2015 - 2035, XP093051010, ISSN: 1743-5889, DOI: 10.2217/nnm-2018-0039
SERRANO GABRIEL, KOCHERGINA IULIA, ALBORS ARTURO, DIAZ EVA, OROVAL MAR, HUESO GUILLEN, SERRANO JUAN M: "Liposomal Lactoferrin as Potential Preventative and Cure for COVID-19", INTERNATIONAL JOURNAL OF RESEARCH IN HEALTH SCIENCES, vol. 8, no. 1, 22 April 2020 (2020-04-22), pages 08 - 15, XP055852408, DOI: 10.5530/ijrhs.8.1.3
DE CARVALHO CARLOS ALBERTO MARQUES, DA ROCHA MATOS ALINE, CAETANO BRAULIA COSTA, DE SOUSA JUNIOR IVANILDO PEDRO, DA COSTA CAMPOS S: "In Vitro Inhibition of SARS-CoV-2 Infection by Bovine Lactoferrin", BIORXIV, pages 1 - 4, XP093051012, Retrieved from the Internet [retrieved on 20230601], DOI: 10.1101/2020.05.13.093781
CAMPIONE ELENA, LANNA CATERINA, COSIO TERENZIO, ROSA LUIGI, CONTE MARIA PIA, IACOVELLI FEDERICO, ROMEO ALICE, FALCONI MATTIA, DEL : "Pleiotropic effect of Lactoferrin in the prevention and treatment of COVID-19 infection: randomized clinical trial, in vitro and in silico preliminary evidence s", BIORXIV, 17 August 2020 (2020-08-17), pages 1 - 8, XP055953776, Retrieved from the Internet [retrieved on 20220823], DOI: 10.1101/2020.08.11.244996
MIRABELLI CARMEN, WOTRING JESSE W., ZHANG CHARLES J., MCCARTY SEAN M., FURSMIDT REID, FRUM TRISTAN, KADAMBI NAMRATA S., AMIN ANYA : "Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19", BIORXIV, pages 1 - 36, XP055872688, Retrieved from the Internet [retrieved on 20211214], DOI: 10.1101/2020.05.27.117184
TAI WANBO; HE LEI; ZHANG XIUJUAN; PU JING; VORONIN DENIS; JIANG SHIBO; ZHOU YUSEN; DU LANYING: "Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine", CELLULAR & MOLECULAR IMMUNOLOGY, NATURE PUBLISHING GROUP UK, LONDON, vol. 17, no. 6, 19 March 2020 (2020-03-19), London, pages 613 - 620, XP037153214, ISSN: 1672-7681, DOI: 10.1038/s41423-020-0400-4
MATTIA MIOTTO; LORENZO DI RIENZO; LEONARDO B\`O; ALBERTO BOFFI; GIANCARLO RUOCCO; EDOARDO MILANETTI: "Molecular mechanisms behind anti SARS-CoV-2 action of lactoferrin", ARXIV.ORG, CORNELL UNIVERSITY LIBRARY, 201 OLIN LIBRARY CORNELL UNIVERSITY ITHACA, NY 14853, 14 July 2020 (2020-07-14), 201 Olin Library Cornell University Ithaca, NY 14853 , XP081929706, DOI: 10.3389/fmolb.2021.607443
JIANSHE LANG, NING YANG, JIEJIE DENG, KANGTAI LIU, PENG YANG, GUIGEN ZHANG, CHENGYU JIANG, ROBERT GERAGHTY: "Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 6, no. 8, 1 August 2011 (2011-08-01), pages e23710, XP055765756, DOI: 10.1371/journal.pone.0023710
ABD ELWAKIL MAHMOUD M, MABROUK MOUSTAFA T, HELMY MAGED W, ABDELFATTAH ELSAYEDA-ZEINAB A, KHISTE SACHIN K, ELKHODAIRY KADRIA A, ELZ: "Inhalable lactoferrin–chondroitin nanocomposites for combined delivery of doxorubicin and ellagic acid to lung carcinoma", NANOMEDICINE, vol. 13, no. 16, 1 August 2018 (2018-08-01), GB , pages 2015 - 2035, XP093051010, ISSN: 1743-5889, DOI: 10.2217/nnm-2018-0039
SERRANO GABRIEL, KOCHERGINA IULIA, ALBORS ARTURO, DIAZ EVA, OROVAL MAR, HUESO GUILLEN, SERRANO JUAN M: "Liposomal Lactoferrin as Potential Preventative and Cure for COVID-19", INTERNATIONAL JOURNAL OF RESEARCH IN HEALTH SCIENCES, vol. 8, no. 1, 22 April 2020 (2020-04-22), pages 08 - 15, XP055852408, DOI: 10.5530/ijrhs.8.1.3
DE CARVALHO CARLOS ALBERTO MARQUES, DA ROCHA MATOS ALINE, CAETANO BRAULIA COSTA, DE SOUSA JUNIOR IVANILDO PEDRO, DA COSTA CAMPOS S: "In Vitro Inhibition of SARS-CoV-2 Infection by Bovine Lactoferrin", BIORXIV, pages 1 - 4, XP093051012, Retrieved from the Internet
CAMPIONE ELENA, LANNA CATERINA, COSIO TERENZIO, ROSA LUIGI, CONTE MARIA PIA, IACOVELLI FEDERICO, ROMEO ALICE, FALCONI MATTIA, DEL : "Pleiotropic effect of Lactoferrin in the prevention and treatment of COVID-19 infection: randomized clinical trial, in vitro and in silico preliminary evidence s", BIORXIV, 17 August 2020 (2020-08-17), pages 1 - 8, XP055953776, Retrieved from the Internet
MIRABELLI CARMEN, WOTRING JESSE W., ZHANG CHARLES J., MCCARTY SEAN M., FURSMIDT REID, FRUM TRISTAN, KADAMBI NAMRATA S., AMIN ANYA : "Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19", BIORXIV, pages 1 - 36, XP055872688, Retrieved from the Internet
TAI WANBO; HE LEI; ZHANG XIUJUAN; PU JING; VORONIN DENIS; JIANG SHIBO; ZHOU YUSEN; DU LANYING: "Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine", CELLULAR & MOLECULAR IMMUNOLOGY, NATURE PUBLISHING GROUP UK, LONDON, vol. 17, no. 6, 19 March 2020 (2020-03-19), London, pages 613 - 620, XP037153214, ISSN: 1672-7681, DOI: 10.1038/s41423-020-0400-4
Attorney, Agent or Firm:
GREER, Stephanie (PR)
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